Phenotype Images associated with this Allele

Nomenclature

Symbol:	Ciroz^b2b1167Clo
Name:	ciliated left-right organizer protein containing ZP-N domains; Bench to Bassinet Program (B2B/CVDC), mutation 1167 Cecilia Lo
MGI ID:	MGI:5431499
Synonyms:	Glow

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 1167-020-LB shows heterotaxy with right lung isomerism	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-020-LB exhibits TGA	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	EFIC Summary	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Serial 2D EFIC image stack in the coronal plane of mutant 1167-020-LB reveals TGA (S,D,D), AVSD, mVSD, ventricular noncompaction, and right lung isomerism Click thumbnail to play movie.	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-003-4 (E15.5) exhibits dextrocardia with right aortic arch, normal relative great artery positioning and mid-live liver	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	EFIC Summary	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Serial 2D EFIC image stack in the coronal plane of mutant fetus 1167-003-4 (E15.5) reveals DORV {A,L,L}, AVSD, and right pulmonary isomerism Click thumbnail to play movie.	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-003-1 (E15.5) is diagnosed with DORV by EFIC	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	EFIC Summary	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Serial 2D EFIC image stack of 1167-003-1 (E15.5) in the coronal imaging plane reveals DORV, AVSD, muscular VSD, and ventricular non-compaction Click thumbnail to play movie.	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Ultrasound color flow imaging in the transverse plane of fetus 1167-003-1 (E15.5) showed an endocardial cushion defect indicative of an atrioventricular septal defect (AVSD)	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Ultrasound color flow imaging in the frontal view of fetus 1167-003-1 (E15.5) showed the aorta and pulmonary artery side by side emerging from RV, with a subaortic VSD suggesting a DORV	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-004-LA exhibits situs inversus totalis	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-003-NA exhibits levocardia with right aortic arch and normal lung lobation	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	EFIC Summary	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Serial 2D EFIC image stack in the coronal plane of 1167-003-NA reveals right aortic arch, bilateral PDA, thickened ventricular wall Click thumbnail to play movie.	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-004-LA shows inverted kidney positioning	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Immunofluorescence of cross-sections of kidney proximal tubules show very long cilia (red)	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-018-LA exhibits heterotaxy with dextrocardia with normal gut situs and hypoplastic thymus	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Mutant 1167-018-LA presents with TGA and hypoplastic morphological RV	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	EFIC Summary	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo
	Serial 2D EFIC image stack in the coronal plane of 1167-018-LA reveals dextrocardia, D-TGA (A,D,D), hypoplastic mRV, unbalanced AVSD, mVSD, dual IVC, malalignment of OFT (Ao anterior to PA), and right atrial isomerism Click thumbnail to play movie.	Ciroz^b2b1167Clo/Ciroz^b2b1167Clo	C57BL/6J-Ciroz^b2b1167Clo

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