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Phenotype Images associated with this Allele
Nomenclature
Symbol: Gm572b2b1167Clo
Name: predicted gene 572; Bench to Bassinet Program (B2B/CVDC), mutation 1167 Cecilia Lo
MGI ID: MGI:5431499
Synonyms: Glow
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1167-020-LB shows heterotaxy with right lung isomerismGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-020-LB exhibits TGAGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
EFIC SummaryGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Serial 2D EFIC image stack in the coronal plane of mutant 1167-020-LB reveals TGA (S,D,D), AVSD, mVSD, ventricular noncompaction, and right lung isomerism
Click thumbnail to play movie.		Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-003-4 (E15.5) exhibits dextrocardia with right aortic arch, normal relative great artery positioning and mid-live liverGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
EFIC SummaryGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Serial 2D EFIC image stack in the coronal plane of mutant fetus 1167-003-4 (E15.5) reveals DORV {A,L,L}, AVSD, and right pulmonary isomerism
Click thumbnail to play movie.		Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-003-1 (E15.5) is diagnosed with DORV by EFICGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
EFIC SummaryGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Serial 2D EFIC image stack of 1167-003-1 (E15.5) in the coronal imaging plane reveals DORV, AVSD, muscular VSD, and ventricular non-compaction
Click thumbnail to play movie.		Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Ultrasound color flow imaging in the transverse plane of fetus 1167-003-1 (E15.5) showed an endocardial cushion defect indicative of an atrioventricular septal defect (AVSD)Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Ultrasound color flow imaging in the frontal view of fetus 1167-003-1 (E15.5) showed the aorta and pulmonary artery side by side emerging from RV, with a subaortic VSD suggesting a DORVGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-004-LA exhibits situs inversus totalisGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-003-NA exhibits levocardia with right aortic arch and normal lung lobationGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
EFIC SummaryGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Serial 2D EFIC image stack in the coronal plane of 1167-003-NA reveals right aortic arch, bilateral PDA, thickened ventricular wall
Click thumbnail to play movie.		Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-004-LA shows inverted kidney positioningGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Immunofluorescence of cross-sections of kidney proximal tubules show very long cilia (red)Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-018-LA exhibits heterotaxy with dextrocardia with normal gut situs and hypoplastic thymusGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Mutant 1167-018-LA presents with TGA and hypoplastic morphological RVGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
EFIC SummaryGm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
Serial 2D EFIC image stack in the coronal plane of 1167-018-LA reveals dextrocardia, D-TGA (A,D,D), hypoplastic mRV, unbalanced AVSD, mVSD, dual IVC, malalignment of OFT (Ao anterior to PA), and right atrial isomerism
Click thumbnail to play movie.		Gm572b2b1167Clo/Gm572b2b1167CloC57BL/6J-Gm572b2b1167Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory