About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Lrp1b2b1554Clo
Name: low density lipoprotein receptor-related protein 1; Bench to Bassinet Program (B2B/CVDC), mutation 1554 Cecilia Lo
MGI ID: MGI:5437079
Synonyms: Marshmellow
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1554-004-1 (E14.5) exhibits gastroschisis with liver and gut outside the abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits narrowed pulmonary outflowLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits narrowed pulmonary outflowLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Serial 2D EFIC image stack in the coronal plane of 1554-004-1 (E14.5) reveals AVSD (or closing interventricular foramen), small PA
Click thumbnail to play movie.		Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits gastroschsis with liver protruding outside of abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-4-2 exhibits narrowed pulmonary stenosisLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant 1554-004-2 (E14.5) shows pulmonary stenosisLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits body wall closure defect with liver protruding outside of abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-004-1 (E14.5) exhibits body wall closure defect with liver protruding outside of abdominal cavity (celoschisis)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
EFIC SummaryLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Serial 2D EFIC image stack of mutant fetus 1554-004-2 (E14.5) shows DORV with pulmonary stenosis and AVSD
Click thumbnail to play movie.		Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits single outflow tract with abdominal organ projecting into thoracic cavity, indicating a diaphragmatic herniaLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits single outflow tract with abdominal organ projecting into thoracic cavity, indicating a diaphragmatic herniaLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits single outflow tract with abdominal organ protruding into chest cavity indicating diaphragmatic herniaLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant 1554-007-1 exhibits umbilical herniation indicative of an omphalocele type body wall closure defectLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Mutant fetus 1554-007-1 (E14.5) exhibits a single outflow tract, indicating persistent truncus arteriosus (PTA)Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
EFIC SummaryLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Serial 2D EFIC image stack in the coronal plane of 1554-007-1 (E16.5) reveals persistence truncus arteriosis (PTA/Type II) hypoplastic PA {S,D,D}
Click thumbnail to play movie.		Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Color flow spectral Doppler imaging of mutant 1554-007-1 (E16.5) in the frontal view shows a single outflow tract suggesting PTA with regurgitation and VSD
Click thumbnail to play movie.		Lrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Snapshot of color flwo spectral Doppler movie of mutant 1554-007-1 (E16.5) in the frontal view shows a single outflow tract suggesting PTA and VSDLrp1b2b1554Clo/Lrp1b2b1554CloC57BL/6J-Lrp1b2b1554Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory