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Phenotype Images associated with this Allele
Nomenclature
Symbol: Megf8b2b1702.2Clo
Name: multiple EGF-like-domains 8; Bench to Bassinet Program (B2B/CVDC), mutation 1702, subline 2 Cecilia Lo
MGI ID: MGI:5437080
Synonyms: TLC
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1702-007-1 (E16.5) exhibits dextrocardia and displaced outflow tracts, later diagnosed as Taussig-Bing type double outlet right ventricle (DORV) by ECM histopathology.Megf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
EFIC SummaryMegf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Serial 2D EFIC image stack in the coronal plane of 1702-007-1 (E16.5) reveals dextrocardia, Taussig-Bing type double outlet right ventricle, and atrioventricular septal defect (AVSD) {I,L,L].
Click thumbnail to play movie.		Megf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Mutant 1702-007-1 (E16.5) presents with dextrogastria and a hypoplastic spleen.Megf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Mutant 1702-007-1 (E16.5) shows a hypoplastic thymus.Megf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Mutant 1702-007-1 (E15.5) exhibits petechiae, left eye anophthalmia, short snout, micrognathia, and is runted.Megf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Mutant 1702-007-1 (E15.5) exhibits right eye microphthalmia.Megf8b2b1702.2Clo/Megf8b2b1702.2CloC57BL/6J-Megf8b2b1702.2Clo
b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory