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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b227Clo
Name: Mutant line 227; Bench to Bassinet Program (B2B/CVDC), mutation 227 Cecilia Lo
MGI ID: MGI:5437098
Synonyms: Scrappy
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 227-002-NC exhibits dextrocardia with duplicated inferior vena cava (IVC) and parallel outflow tracts which is diagnosed as DORV by EFIC imagingb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-002-NC exhibits dextrocardia with inverted liver lobationb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack of 227-007-NC in the coronal plane reveals dextrocardia, DORV, AVSD (subaortic) {A,L,L}
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-127-LB displays dextrocardia, dextrogastria and left sided liver indicative of heterotaxyb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-127-LB displays dextrocardia, dextrogastria and a small spleenb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack in the coronal plane of 227-127-LB reveals mirror image dextrocardia and mVSD
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-127-LB displays dextrogastria and midline liverb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Videomicroscopy of mutant 227-127-LB airway cilia reveals patches of immotile and dyskinetic cilia
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-002-NB displays mesocardia and cystic lungsb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack in the coronal plane of 227-002-NB reveals mesocardia, mVSD, dilated atria/ventricle, lung cysts, and dilated venous return
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-118-LA exhibits dextrocardia with RAA, hypoplastic morphological RV, and dual IVC which is confirmed by EFIC imagingb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
EFIC Summaryb2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack in the coronal plane of 227-118-LA reveals dextrocardia, hypoplastic mRV, mVSD, right atrial isomerism, and dual IVC
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Mutant 227-118-LA has malaligned sternal vertebrab2b227Clo/b2b227CloC57BL/6J-b2b227Clo
Odad2b2b227.1Clo/Odad2b2b227.1CloC57BL/6J-Odad2b2b227.1Clo
Serial 2D EFIC image stack of 227-002-ND in coronal plane reveals ventricular septal hypertrophy
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
b2b227.2Clo/b2b227.2CloC57BL/6J-b2b227.2Clo
2D micro-MRI image stack of 227-085-LA in coronal plane reveals ventricular hypertrophy
Click thumbnail to play movie.		b2b227Clo/b2b227CloC57BL/6J-b2b227Clo
b2b227.2Clo/b2b227.2CloC57BL/6J-b2b227.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory