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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah11b2b1727Clo
Name: dynein, axonemal, heavy chain 11; Bench to Bassinet Program (B2B/CVDC) mutation 1727, Cecilia Lo
MGI ID: MGI:5437727
Synonyms: Mickey
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1727-002-LA displays heterotaxy indicated by dextrocardia with lung lobation and levogastriaDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Mutant 1727-002-LA displays levogastria, small abnormally shaped spleen and necrotic tissue on liver lobe indicative of possible biliary duct obstruction.Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Mutant 1727-002-LA displays dextrocardia with right aortic archDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
EFIC summaryDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Serial 2D EFIC image stack of 1727-002-LA in coronal plane reveals dextrocardia {I,L,I} and perimembranous VSD
Click thumbnail to play movie.		Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Mutant 1727-002-LA displays bilateral duplex kidneys and severe hydroureter and hydronephrosis of the left kidney.Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Mutant 1727-002-LA displays severe hydronephrosis and severe hydronephorsis of the left kidney.Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Mutant 1727-002-LE displays mirror image placement of the visceral organs, indicating situs inversus totalis.Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Videomicroscopy of mutant 1727-002-LE airway reveals hyperkinetic/immotile/dyskinetic ciliary motion
Click thumbnail to play movie.		Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Quantification of ciliary beat frequency (CBF) from mutant 1727-002-LE reveals hyperkinetic ciliary beatDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Mutant 1727-003-1 (E 15.5) displays levocardia with right aortic archDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
EFIC summaryDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
2D EFIC image stack of 1727-003-1 (E15.5) in the coronal plane reveals DORV {S,D,D}, AVSD (subaortic), right aortic arch, and isolated left subclavian artery forming vascular sling
Click thumbnail to play movie.		Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
2D fetal ultrasound imaging of mutant 1727-003-1 (E 15.5) in the transverse view shows endocardial cushion defect suggesting AVSDDnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Color flow spectral Doppler ultrasound imaging of mutant 1727-003-1 (E 15.5) in the frontal view shows pulmonary artery with overriding aorta, suggesting DORV with subaortic VSD.Dnah11b2b1727Clo/Dnah11b2b1727CloC57BL/6J-Dnah11b2b1727Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory