About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Cntrlb2b1468.1Clo
Name: centriolin; Bench to Bassinet Program (B2B/CVDC), mutation 1468, subline 1 Cecilia Lo
MGI ID: MGI:5438058
Synonyms: Cep110b2b1468.1Clo, Hunchback
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1468-003-4 (E15.5) displays right aortic arch, hypoplastic transverse arch, and malpositioning of the great arteries which is diagnosed as double outlet right ventricle (DORV) by ECM histopathology.Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
EFIC SummaryCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D ECM image stack of 1468-003-4 (E15.5) in coronal plane reveals double outlet right ventricle (DORV) {S,D,D}, right aortic arch (RAA), hypoplastic transverse aortic arch, spongy right ventricle, and dilated atria.
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D micro-CT image stack in the coronal plane of 1468-003-4 (E15.5) reveals DORV, subaoctic VSD, right aortic arch
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Kidneys of mutant 1468-003-4 are hydronephrotic and hydroureter. Some glomerular cysts are presentCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Mutant 1468-003-1 (E 15.5) is runted with small eyesCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Mutant 1468-003-1 (E15.5) presents with a small right ventricle confirmed by ECM histopathology.Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
EFIC SummaryCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D EFIC image stack in the coronal plane of 1468-003-1 (E15.5) reveals hypoplastic right ventricle with normal pulmonary artery size.
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Kidneys of mutant 1468-003-1 shows glomerular and tubular cysts as well as hydronephrosis and hydroureterCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
EFIC SummaryCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D ECM image stack of 1468-003-3 (E15.5) in the coronal plane reveals double outlet right ventricle (DORV) {S,D,D}, atrioventricular septal defect (AVSD) , pulmonary artery stenosis, and ventricular non-compaction.
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Kidney of mutant 1468-003-3 has glomerular cysts and possibly a few tubular cystsCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory