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Phenotype Images associated with this Allele
Nomenclature
Symbol: Cntrlb2b1468.1Clo
Name: centriolin; Bench to Bassinet Program (B2B/CVDC), mutation 1468, subline 1 Cecilia Lo
MGI ID: MGI:5438058
Synonyms: Cep110b2b1468.1Clo, Hunchback
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1468-003-4 (E15.5) displays right aortic arch, hypoplastic transverse arch, and malpositioning of the great arteries which is diagnosed as double outlet right ventricle (DORV) by ECM histopathology.Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
EFIC SummaryCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D ECM image stack of 1468-003-4 (E15.5) in coronal plane reveals double outlet right ventricle (DORV) {S,D,D}, right aortic arch (RAA), hypoplastic transverse aortic arch, spongy right ventricle, and dilated atria.
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D micro-CT image stack in the coronal plane of 1468-003-4 (E15.5) reveals DORV, subaoctic VSD, right aortic arch
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Kidneys of mutant 1468-003-4 are hydronephrotic and hydroureter. Some glomerular cysts are presentCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Mutant 1468-003-1 (E 15.5) is runted with small eyesCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Mutant 1468-003-1 (E15.5) presents with a small right ventricle confirmed by ECM histopathology.Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
EFIC SummaryCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D EFIC image stack in the coronal plane of 1468-003-1 (E15.5) reveals hypoplastic right ventricle with normal pulmonary artery size.
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Kidneys of mutant 1468-003-1 shows glomerular and tubular cysts as well as hydronephrosis and hydroureterCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
EFIC SummaryCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Serial 2D ECM image stack of 1468-003-3 (E15.5) in the coronal plane reveals double outlet right ventricle (DORV) {S,D,D}, atrioventricular septal defect (AVSD) , pulmonary artery stenosis, and ventricular non-compaction.
Click thumbnail to play movie.		Cntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Kidney of mutant 1468-003-3 has glomerular cysts and possibly a few tubular cystsCntrlb2b1468.1Clo/Cntrlb2b1468.1CloC57BL/6J-Cntrlb2b1468.1Clo
b2b1468Clo/b2b1468CloC57BL/6J-b2b1468Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory