Phenotype Images associated with this Allele

Nomenclature

Symbol:	Drc1^b2b1654Clo
Name:	dynein regulatory complex subunit 1; Bench to Bassinet Program (B2B/CVDC), mutation 1654 Cecilia Lo
MGI ID:	MGI:5438062
Synonyms:	Aardvark, Ccdc164^b2b1654Clo

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 1654-002-MNA displays levocardia with dual hepatic vein	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	EFIC Summary	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Serial 2D EFIC image stack of 1654-002-MNC in the coronal plane reveals levocardia, bilateral hepatic vein and azygous connection Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Serial 2D micro-MRI image stack in the coronal plane of 1654-002-MNA reveals heterotaxy with levocardia and dextrogastria, bilateral hepatic vein and azygous venous connection, ambiguous atrium, right lung isomerism Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-002-MNA presents with micrognathia	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-002-MNA presents with malaligned sternal vertebra	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-002-MNA displays dextrogastria with malformed spleen	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-003-LA displays heterotaxy indicated by dextrocardia with levogastria	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-003-LA displays dextrocardia	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	EFIC Summary	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Serial 2D EFIC image stack of 1654-003-LA in the coronal plane reveals mirror image dextrocardia {I,L,I} Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Videomicroscopy of mutant 1654-003-LA reveals dyskinetic airway cilia Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-007-LA displays heterotaxy indicated by dextrocardia with inverted liver lobation, left-sided pancreas and spleen, right-sided stomach	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	EFIC Summary	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Serial 2D EFIC image stack of 1654-007-LA in the coronal plane reveals mirror image dextrocardia Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-007-LA displays left-sided pancreas and spleen and right-sided stomach	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Videomicroscopy of mutant 1654-007-LA airway reveals dyskinetic and immotile cilia Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-005-1 exhibits dextrocardia with dual IVC and parallel outflow tracts, which is confirmed as TGA by EFIC imaging	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	EFIC Summary	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Serial 2D EFIC image stack of 1654-005-1 (E15.5) in the coronal plane reveals heterotaxy, dextrocardia, TGA {A,L,L}, AVSD, interrupted aortic arch (type-b), bilateral IVS, left bronchial isomerism Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1654-005-1 has asplenia and left liver isomerism with a right-sided stomach and pancreas	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Mutant 1625-025-LA exhibits situs inversus totalis, which is indicated by dextrocardia and dextrogastria	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	EFIC Summary	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo
	Serial 2D EFIC image stack in the coronal plane of 1624-025-LA reveals mirror image dextrocardia {I,L,L} Click thumbnail to play movie.	Drc1^b2b1654Clo/Drc1^b2b1654Clo	C57BL/6J-Drc1^b2b1654Clo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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