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Phenotype Images associated with this Allele
Nomenclature
Symbol: Mfn2tm1.1Mzhe
Name: mitofusin 2; targeted mutation 1.1, Ming Zheng
MGI ID: MGI:5445195
Synonyms: MFN2f
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Autophagosome accumulation in Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe Myl2tm1(cre)Krc/Myl2+ heartsMfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Myl2tm1(cre)Krc/Myl2+		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Impaired lipid metabolism and accumulation of lipofuscin granules in Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe Myl2tm1(cre)Krc/Myl2+ cardiomyocytesMfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Myl2tm1(cre)Krc/Myl2+		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe Myl2tm1(cre)Krc/Myl2+ cardiomyocytes show a greater loss of mitochondrial membrane potential following ischemia-reperfusionMfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Myl2tm1(cre)Krc/Myl2+		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Enlarged mitochondria in Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe Myl2tm1(cre)Krc/Myl2+ heartMfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Myl2tm1(cre)Krc/Myl2+		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory