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Phenotype Images associated with this Allele
Nomenclature
Symbol: Vsx2tm1.1Itl
Name: visual system homeobox 2; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID: MGI:5449355
Synonyms: R200Q, Vsx2R200Q
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Small eyes in various Vsx2 homozygous mutantsVsx2tm1.1Itl/Vsx2tm1.1Itlinvolves: 129S6/SvEvTac
Vsx2tm1.1Eml/Vsx2tm1.1Emlinvolves: 129S1/Sv * 129X1/SvJ
Vsx2or-J/Vsx2or-Jinvolves: 129S1/Sv
Ocular histology and neurogenesis in homozygous Vsx2 mutantsVsx2tm1.1Itl/Vsx2tm1.1Itlinvolves: 129S6/SvEvTac
Vsx2tm1.1Eml/Vsx2tm1.1Emlinvolves: 129S1/Sv * 129X1/SvJ
Vsx2or-J/Vsx2or-Jinvolves: 129S1/Sv
Microphthalmia severity in Vsx2 mutants correlates with the expression levels of Mitf and Otx1Vsx2tm1.1Itl/Vsx2tm1.1Itlinvolves: 129S6/SvEvTac
Vsx2tm1.1Eml/Vsx2tm1.1Emlinvolves: 129S1/Sv * 129X1/SvJ
Vsx2or-J/Vsx2or-Jinvolves: 129S1/Sv
The dominant negative MitfMi allele restores retinal development in the Vsx2 mutantsVsx2tm1.1Itl/Vsx2tm1.1Itlinvolves: 129S6/SvEvTac
Vsx2tm1.1Eml/Vsx2tm1.1Emlinvolves: 129S1/Sv * 129X1/SvJ
Vsx2or-J/Vsx2or-Jinvolves: 129S1/Sv
MitfMi/Mitf+
Vsx2or-J/Vsx2or-J		involves: 129S1/Sv * 129X1/SvJ
MitfMi/Mitf+
Vsx2tm1.1Itl/Vsx2tm1.1Itl		involves: 129S1/Sv * 129S6/SvEvTac
MitfMi/Mitf+
Vsx2tm1.1Eml/Vsx2tm1.1Eml		involves: 129S1/Sv * 129X1/SvJ
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory