Phenotype Images associated with this Allele

Nomenclature

Symbol:	Vsx2^tm1.1Eml
Name:	visual system homeobox 2; targeted mutation 1.1, Edward M Levine
MGI ID:	MGI:5449356
Synonyms:	R227W, Vsx2^R227W

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Small eyes in various Vsx2 homozygous mutants	Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S6/SvEvTac
		Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
		Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv
	Ocular histology and neurogenesis in homozygous Vsx2 mutants	Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S6/SvEvTac
		Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
		Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv
	Eye circumference of various Vsx2 mutants	Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
		Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv
		Vsx2^or-J/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
	Microphthalmia severity in Vsx2 mutants correlates with the expression levels of Mitf and Otx1	Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S6/SvEvTac
		Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
		Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv
	PITX2+ mesenchymal cells fill the vitreal chamber of the retina in homozygous Vsx2 mutants	Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
		Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv
	The dominant negative Mitf^Mi allele restores retinal development in the Vsx2 mutants	Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S6/SvEvTac
		Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
		Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv
		Mitf^Mi/Mitf⁺ Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv * 129X1/SvJ
		Mitf^Mi/Mitf⁺ Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S1/Sv * 129S6/SvEvTac
		Mitf^Mi/Mitf⁺ Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ
	Invasion of periocular mesenchyme into the vitreal chamber in Vsx2^tm1.1Eml/Vsx2^tm1.1Eml eyes	Vsx2^tm1.1Eml/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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