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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ngftm1.1Blhe
Name: nerve growth factor; targeted mutation 1.1, Barbara L Hempstead
MGI ID: MGI:5461488
Synonyms: proNgf-HA
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Adult Ngftm1.1Blhe/Ngf+ mice exhibit dilated cardiomyopathy and fibrosis and this phentoype is rescued in Ngfrtm1Jae/Ngfrtm1Jae Ngftm1.1Blhe/Ngf+ miceNgftm1.1Blhe/Ngf+B6.Cg-Ngftm1.1Blhe
Ngftm1.1Blhe/Ngf+
Ngfrtm1Jae/Ngfrtm1Jae		B6.Cg-Ngftm1.1Blhe Ngfrtm1Jae
Hearts from adult Ngftm1.1Blhe/Ngf+ mice exhibit microvascular damage and hearts from juveniles show early signs of endothelial cell activation and microvascular damageNgftm1.1Blhe/Ngf+B6.Cg-Ngftm1.1Blhe
Abnormalities in the microvasculature of hearts from Ngftm1.1Blhe/Ngf+ mice and rescue of the phenotype in Ngfrtm1Jae/Ngfrtm1Jae Ngftm1.1Blhe/Ngf+ miceNgftm1.1Blhe/Ngf+B6.Cg-Ngftm1.1Blhe
Ngftm1.1Blhe/Ngf+
Ngfrtm1Jae/Ngfrtm1Jae		B6.Cg-Ngftm1.1Blhe Ngfrtm1Jae
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory