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Phenotype Images associated with this Allele
Nomenclature
Symbol: Rhotm2.1Kpal
Name: rhodopsin; targeted mutation 2.1, Krzysztof Palczewski
MGI ID: MGI:5474849
Synonyms: RhoE150K
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Severe retinal degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma mice and less severe degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal miceLrattm1Kpal/Lrattm1Kpal
Rhotm2.1Kpal/Rhotm2.1Kpal		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Gnat1tm1Clma/Gnat1tm1Clma
Rhotm2.1Kpal/Rhotm2.1Kpal		involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Progressive retinal degeneration in heterozygous and homozygous Rhotm2.1Kpal miceRhotm2.1Kpal/Rho+involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Rhotm2.1Kpal/Rhotm2.1Kpalinvolves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Retinal abnormalities in heterozygous and homozygous Rhotm2.1Kpal miceRhotm2.1Kpal/Rho+involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Rhotm2.1Kpal/Rhotm2.1Kpalinvolves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Rhodopsin mislocalization, fundus autofluorescent spots, and Muller/macrophage/microglial cell activation in retinas of Rhotm2.1Kpal/Rhotm2.1Kpal miceRhotm2.1Kpal/Rhotm2.1Kpalinvolves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Reduced thickness of rod photoreceptor cell layers in Rhotm2.1Kpal/Rhotm2.1Kpal retinaRhotm2.1Kpal/Rhotm2.1Kpalinvolves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory