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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b1879Clo
Name: Mutant line 1879; Bench to Bassinet Program (B2B/CVDC), mutation 1879 Cecilia Lo
MGI ID: MGI:5476173
Synonyms: Carter
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1879-002-NA shows abnormal placement of the outflow with malformed pulmonary trunk and is diagnosed with DORV by EFIC imagingb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
EFIC Summaryb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Serial 2D EFIC image stack in the coronal plane of 1879-002-NA reveals DORV, subaortic VSD, and biventricular hypertrophy
Click thumbnail to play movie.		b2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-002-NA has a short snout, micrognathia, domed-shaped head, short limbs, and abnormally attached hindlimbsb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-002-NA has midline defect with unfused sternumb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-002-1 (E16.5) exhibits abnormally attached hindlimbsb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-002-1 (E16.5) exhibits a cleft palateb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-002-1 (E16.5) presents with an unfused sternumb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
EFIC Summaryb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Serial 2D EFIC image stack in the coronal plane of mutant 1879-002-1 (E16.5) reveals overriding aorta, PA hypoplasia, and biventricular hypertrophy
Click thumbnail to play movie.		b2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Color flow spectral Doppler imaging of mutant 1879-002-1 (E16.5) in the saggital view shows aorta overriding on the ventricular septum, VSD, blood flow only can be detected in aorta. Notice a small vessel beside aorta, but no blood flow inside. This together suggests PA, VSD
Click thumbnail to play movie.		b2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Snapshot of video of Color flow spectral Doppler imaging for mutant 1879-002-1 (E16.5) in the sagittal view shows aorta overriding on the ventricular septum, VSD, blood flow only can be detected in aorta. Notice a small vessel beside aorta, but no blood flow inside. This together suggests PA, VSDb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-2 (E17.5) presents with hydrops, short snout, and abnormal flexure of the hindlimbsb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-2 (E17.5) exhibits a cleft palateb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-2 (E17.5) has hypoplastic thymusb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-2 (E17.5) has malaligned outflow tracts shown to be DORV by EFIC imagingb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
EFIC Summaryb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Serial 2D EFIC image stack of 1879-004-2 (E17.5) in the coronal plane reveals DORV {S,D,D}, subaortic AVSD, ventricular myocardial non-compaction
Click thumbnail to play movie.		b2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-1 (E17.5) presents with hydrops and abnormally attached hindlimbsb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-1 (E17.5) exhibits a hypoplastic thymusb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-004-1 (E17.5) exhibits a hypoplastic transverse arch and overriding aorta, which was confirmed by EFIC imagingb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
EFIC Summaryb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Serial 2D EFIC image stack in the coronal plane of mutant 1879-004-1 (E17.5) reveals overriding aorta, pmVSD, hypoplastic Ao, and ventricular myocardial non-compaction
Click thumbnail to play movie.		b2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
Adamts6b2b1879.1Clo/Adamts6b2b1879.1CloC57BL/6J-Adamts6b2b1879.1Clo
Mutant 1879-006-NB shows kidney agenesisb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
b2b1879.2Clo/b2b1879.2CloC57BL/6J-b2b1879.2Clo
Mutant 1879-006-NC shows kidney agenesisb2b1879Clo/b2b1879CloC57BL/6J-b2b1879Clo
b2b1879.2Clo/b2b1879.2CloC57BL/6J-b2b1879.2Clo
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11/12/2024
MGI 6.24 		The Jackson Laboratory