Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Adamts6^b2b2029Clo
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2029 Cecilia Lo
MGI ID:	MGI:5487287
Synonyms:	Peep

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2029-003-NC exhibits a dilated right ventricle (RV), malaligned great arteries, which is confirmed as double outlet right ventricle by EFIC imaging. The pulmonary artery is dilated, while the ascending aorta is hypoplastic.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	EFIC Summary	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Serial 2D EFIC image stack of 2029-003-NC in the coronal plane reveals double outlet right ventricle (DORV), subaortic VSD, hypoplastic aorta, thick semilunar valves and biventricular hypertrophy Click thumbnail to play movie.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-NC has craniofacial defects comprising of short snout, micrognathia, and dome-shaped head as well as hindlimb anomalies.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-NC presents with a cleft palate	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-NC shows an unfused sternum	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-NC exhibits a hypoplastic thymus	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-NB has craniofacial defects comprising of short snout, micrognathia, and a dome shaped head. This is accompanied by abnormally attached hindlimbs.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-NB has a dilated pulmonary artery (PA) and malaligned great arteries indicating overriding aorta, which was confirmed by EFIC imaging.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	EFIC Summary	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Serial 2D EFIC image stack of 2029-003-NB in the coronal view exhibits overriding aorta, perimembranous VSD, dilated pulmonary artery (PA), thick semilunar valves and biventricular hypertrophy Click thumbnail to play movie.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-2 (E16.5) has a dome-shaped head, micrognathia, and abnormally attached hindlimbs	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-2 (16.5) presents with an unfused sternum	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Mutant 2029-003-2 (E16.5) is exhibits parallel outflow tracts, indicating DORV, which is confirmed by EFIC imaging	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	EFIC Summary	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo
	Serial 2D EFIC image stack in the coronal plane of mutant 2029-003-2 (E16.5) shows DORV, AVSD, and biventricular hypertrophy Click thumbnail to play movie.	Adamts6^b2b2029Clo/Adamts6^b2b2029Clo	C57BL/6J-Adamts6^b2b2029Clo

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