| Mutant 1511-006-1 (E16.5) exhibits right aortic arch (RAA), pulmonary stenosis and malalignment of the great arteries, which was shown to be double outlet right ventricle (DORV) by histopathology | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| EFIC Summary | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Serial 2D EFIC image stack in the coronal plane of 1511-006-1 (E16.5) shows right aortic arch (RAA), PA stenosis, AVSD, Taussig-bing type DORV, subpulmonary VSD and symmetrically positioned SVCs Click thumbnail to play movie. | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) exhibits microphthalmia | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) presents with central polydactyly | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) exhibits facial cleft | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) shows cleft palate with complete failure of the palatal shelves to close | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1611-006-1 (E16.5) presents with cystic kidneys which were confirmed by histopathology, and also observed was malpositionining of the left gonad | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) presents cysts in the tubules and glomeruli | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Immunofluorescence of mutant 1511-006-1 (E16.5) has cilia (red) in dilated collecting duct (green) | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Immunofluorescence of mutant 1511-006-1 (E16.5) has a cystic collecting duct showing only the 3 short cilia (red) | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) has short cilia (red) in cystic collecting duct (green) | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-006-1 (E16.5) has short cilia (red) in cystic renal corpuscle | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-009-ND exhibits dilated aorta with short ascending aorta and possible double outlet right ventricle (DORV), which was confirmed by histopathology | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-009-ND exhibits duplex kidneys with severe hydronephrosis and hydroureter | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| EFIC Summary | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Serial 2D EFIC image stack in the coronal plane of 1511-009-ND shows right aortic arch (RAA), DORV, subaortic VSD, mVSD, and a short ascending aorta that is also dilated Click thumbnail to play movie. | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Serial 2D micro-MRI in the coronal plane of 1511-009-ND reveals bilateral duplex kidney and hydronephrosis Click thumbnail to play movie. | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-009-ND presents bilateral duplex kidneys with hydroureter, hydronephrosis and associated cysts | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Mutant 1511-009-ND presents bilateral duplex kidneys with hydroureter, hydronephrosis and associated cysts | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Immunofluorescence of cilia (red) in ureteric bud (green) of mutant 1511-009-ND. | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Immunofluorescence of cystic collecting ducts (green) in mutant 1511-009-ND reveals very long cilia with knobby tips (red) | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |
| Immunofluorescence of cystic collecting duct (green) in mutant 1511-009-ND reveals the presence of cilia with knobby tips (red) | b2b1511Clo/b2b1511Clo | C57BL/6J-b2b1511Clo |
b2b1511.1Clo/b2b1511.1Clo | C57BL/6J-b2b1511.1Clo |