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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b1511.1Clo
Name: Mutant line 1511.1; Bench to Bassinet Program (B2B/CVDC), mutation 1511, subline 1 Cecilia Lo
MGI ID: MGI:5491229
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1511-006-1 (E16.5) exhibits right aortic arch (RAA), pulmonary stenosis and malalignment of the great arteries, which was shown to be double outlet right ventricle (DORV) by histopathologyb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
EFIC Summaryb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Serial 2D EFIC image stack in the coronal plane of 1511-006-1 (E16.5) shows right aortic arch (RAA), PA stenosis, AVSD, Taussig-bing type DORV, subpulmonary VSD and symmetrically positioned SVCs
Click thumbnail to play movie.
b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) exhibits microphthalmiab2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) presents with central polydactylyb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) exhibits facial cleftb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) shows cleft palate with complete failure of the palatal shelves to closeb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1611-006-1 (E16.5) presents with cystic kidneys which were confirmed by histopathology, and also observed was malpositionining of the left gonadb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) presents cysts in the tubules and glomerulib2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Immunofluorescence of mutant 1511-006-1 (E16.5) has cilia (red) in dilated collecting duct (green)b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Immunofluorescence of mutant 1511-006-1 (E16.5) has a cystic collecting duct showing only the 3 short cilia (red)b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) has short cilia (red) in cystic collecting duct (green)b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-006-1 (E16.5) has short cilia (red) in cystic renal corpuscleb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-009-ND exhibits dilated aorta with short ascending aorta and possible double outlet right ventricle (DORV), which was confirmed by histopathologyb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-009-ND exhibits duplex kidneys with severe hydronephrosis and hydroureterb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
EFIC Summaryb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Serial 2D EFIC image stack in the coronal plane of 1511-009-ND shows right aortic arch (RAA), DORV, subaortic VSD, mVSD, and a short ascending aorta that is also dilated
Click thumbnail to play movie.
b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Serial 2D micro-MRI in the coronal plane of 1511-009-ND reveals bilateral duplex kidney and hydronephrosis
Click thumbnail to play movie.
b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-009-ND presents bilateral duplex kidneys with hydroureter, hydronephrosis and associated cystsb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Mutant 1511-009-ND presents bilateral duplex kidneys with hydroureter, hydronephrosis and associated cystsb2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Immunofluorescence of cilia (red) in ureteric bud (green) of mutant 1511-009-ND.b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Immunofluorescence of cystic collecting ducts (green) in mutant 1511-009-ND reveals very long cilia with knobby tips (red)b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo
Immunofluorescence of cystic collecting duct (green) in mutant 1511-009-ND reveals the presence of cilia with knobby tips (red)b2b1511Clo/b2b1511CloC57BL/6J-b2b1511Clo
b2b1511.1Clo/b2b1511.1CloC57BL/6J-b2b1511.1Clo

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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory