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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2012.1Clo
Name: Mutant line 2012.1; Bench to Bassinet Program (B2B/CVDC), mutation 2012, subline 1 Cecilia Lo
MGI ID: MGI:5491232
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant has parallel outflow tracts indicating possible double outlet right ventricle (DORV), which was confirmed by ECM histopathology.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
EFIC Summaryb2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
Serial 2D ECM image stack in the coronal plane of mutant shows double outlet right ventricle (DORV) and subaortic VSD.
Click thumbnail to play movie.		b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
Mutant has micropthalmia of the right eye.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
Mutant appears to have hypoplastic RV and possible hypertrophy which was confirmed by ECM imaging.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
EFIC Summaryb2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
Serial 2D ECM image stack of mutant in the coronal plane shows unbalanced atrioventricular septal defect (AVSD), small RV, and LV hypertrophy.
Click thumbnail to play movie.		b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
Mutant has severe anopthalmia of the right eye, short snout, and micrognathia.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.1Clo/b2b2012.1CloC57BL/6J-b2b2012.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory