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Phenotype Images associated with this Allele
Nomenclature
Symbol: Prnptm3Lnq
Name: prion protein; targeted mutation 3, Susan Lindquist
MGI ID: MGI:5546407
Synonyms: CJD
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Neuropathologic processes of Prnptm3Lnq/Prnptm3Lnq micePrnptm3Lnq/Prnptm3Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Activation of cell cycle and death markers in Prnptm3Lnq/Prnptm3Lnq (B and E), and Prnptm2Lnq/Prnptm2Lnq (C and F) brainsPrnptm2Lnq/Prnptm2Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Prnptm3Lnq/Prnptm3Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Reactive gliosis in Prnptm3Lnq/Prnptm3Lnq (CJD) brain and neurodegeneration and dilated ventricles in Prnptm2Lnq/Prnptm2Lnq (FFI) brainPrnptm2Lnq/Prnptm2Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Prnptm3Lnq/Prnptm3Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Prion protein aggregates are present in the outer plexiform layer of Prnptm3Lnq/Prnptm3Lnq retinaPrnptm3Lnq/Prnptm3Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Proteinase K resistant prion protein and prion protein aggregates in Prnptm2Lnq/Prnptm2Lnq and Prnptm3Lnq/Prnptm3Lnq brainsPrnptm2Lnq/Prnptm2Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Prnptm3Lnq/Prnptm3Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Activation of cell cycle and death markers in Prnptm3Lnq/Prnptm3Lnq (CJD), and Prnptm2Lnq/Prnptm2Lnq (FFI) micePrnptm2Lnq/Prnptm2Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Prnptm3Lnq/Prnptm3Lnqinvolves: 129P2/OlaHsd * C57BL/6N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory