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Phenotype Images associated with this Allele
Nomenclature
Symbol: Adamts6b2b2187.1Clo
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2187, subline 1, Cecilia Lo
MGI ID: MGI:5547743
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2187-004-NC has a hypoplastic aorta and pulmonary stenosis as well as DORV and biventricular hypertrophy that was confirmed by EFIC imagingb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
EFIC Summaryb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Serial 2D EFIC image stack in the coronal plane of 2187-004-NC shows DORV, subaortic VSD, and biventricular hypertrophy
Click thumbnail to play movie.		b2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NC exhibits a short snout, micrognathia, and abnormal flexure of the hindlimbb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NC has a cleft palateb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NC shows an unfused sternumb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NC exhibits a hypoplastic thymusb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-1 (E16.5) has hydrocephalus, build up of blood in the brain, and hydrops when it was collectedb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-1 (E16.5) exhibits pulmonary stenosis and double outlet right ventricle (DORV) that confirmed EFIC histologyb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
EFIC Summaryb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Serial 2D EFIC image stack in the coronal plane of 2187-004-1 (E16.5) shows double outlet right ventricle (DORV), subaortic VSD, small LV, atrioventricular valve dysplasia, semilunar valve dysplasia, bicuspid aortic valve, and a spongy right ventricle
Click thumbnail to play movie.		b2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Color flow spectral Doppler imaging of mutant fetus 2187-004-1 (E16.5) in the transverse view shows aliasing with increased blood flow through inflow tracts, suggesting atrioventricular valve stenosisb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Color flow spectral Doppler imaging of mutant fetus 2187-004-1 (E16.5) in the sagittal view shows aliasing with increased velocity of blood flow in pulmonary artery (PA), suggesting pulmonary stenosisb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Spectral Doppler imaging of mutant fetus 2187-00401 (E16.5) in the sagittal view detects increased velocity of blood flow in pulmonary artery (PA), suggesting pulmonary stenosis, which is consistent with the findings of color flow imagingb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-006-2 (E15.5) has hindlimbs with abnormal flexure and hydropsb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
EFIC Summaryb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Serial 2D EFIC image stack in the coronal plane of 2187-006-2 (E15.5) shows overriding aorta, pmVSD, mild hypoplastic aorta, and biventricular hypertrophy
Click thumbnail to play movie.		b2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
EFIC Summaryb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Serial 2D EFIC image stack in the coronal plane of 2187-006-4 (E15.5) shows overriding aorta, perimembranous VSD (pmVSD), muscular VSD (mVSD), and biventricular hypertrophy
Click thumbnail to play movie.		b2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NA presents with an unfused sternumb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NC exhibits thymus hypoplasiab2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Mutant 2187-004-NA has a dilated pulmonary and malaligned great arteries, which is shown by EFIC histology to comprise double outlet right ventricle (DORV), and possible biventricular hypertrophyb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
EFIC Summaryb2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Serial 2D EFIC image stack in the coronal plane of 2187-004-NA shows overriding aorta and pmVSD
Click thumbnail to play movie.		b2b2187Clo/b2b2187CloC57BL/6J-b2b2187Clo
Adamts6b2b2187.1Clo/Adamts6b2b2187.1CloC57BL/6J-Adamts6b2b2187.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory