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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ap2b1b2b2321Clo
Name: adaptor-related protein complex 2, beta 1 subunit; Bench to Bassinet Program (B2B/CVDC), mutation 2321 Cecilia Lo
MGI ID: MGI:5552944
Synonyms: Soot
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2321-006-MNE is shows an anterior aorta, RAA, and biventricular hypertrophy which is diagnosed as Taussig-Bing type DORV by EFIC imagingAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
EFIC SummaryAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Serial 2D EFIC image stack in the coronal plane of 2321-006-MNE shows Taussig-Bing DORV {S,D,D}, AVSD, RAA, incomplete vascular ring, dual IVC, right atrial isomerism, and biventricular hypertrophy
Click thumbnail to play movie.		Ap2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-006-MNE presents with micrognathiaAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-006-MNE presents with a cleft palateAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-006-MNE presents with a hypoplastic thymusAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-002-1 (E16.5) exhibits a cleft palateAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-002-1 (E16.5) presents with a hypoplastic thymusAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-002-1 (E16.5) exhibits RAA, a small RV, hypoplastic PA, ventricular hypertrophy, and parallel outflow tracts which is diagnosed as Taussig-Bing type DORV by EFIC imagingAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
EFIC SummaryAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Serial 2D EFIC image stack in the coronal plane of 2321-002-1 (E16.5) shows RAA, Taussig-Bing DORV, small RV, mVSD, AVSD, hypoplastic PA, left pulmonary artery arises from left barchiocephalic artery, and biventricular hypertrophy
Click thumbnail to play movie.		Ap2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Color flow spectral Doppler imaging of mutant 2321-002 (E16.5) in the sagittal view shows only one great artery originating from RV, suggesting PTA. EFIC imaging demonstrated it was PS with DORV
Click thumbnail to play movie.		Ap2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-006-NB presents with micrognathiaAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-006-NB has parallel outflow tracts and possible overriding aorta, which is confirmed by EFIC imagingAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
EFIC SummaryAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Serial 2D EFIC image stack of 2321-006-NB in the coronal plane reveals overriding aorta and pmVSD
Click thumbnail to play movie.		Ap2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Serial 2D micro-MRI image stack of 2321-006-NB in the coronal plane reveals perimembranous VSD (pmVSD) and overriding aorta
Click thumbnail to play movie.		Ap2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Mutant 2321-004-NC exhibits parallel outflow tracts and has overriding aorta by EFIC imagingAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
EFIC SummaryAp2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
Serial 2D EFIC image stack in the coronal plane of 2321-004-NC shows overriding aorta and pmVSD
Click thumbnail to play movie.		Ap2b1b2b2321Clo/Ap2b1b2b2321CloC57BL/6J-Ap2b1b2b2321Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory