About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Myh10b2b2437Clo
Name: myosin, heavy polypeptide 10, non-muscle; Bench to Bassinet Program (B2B/CVDC), mutation 2437 Cecilia Lo
MGI ID: MGI:5552947
Synonyms: Moe
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2437-005-3 (E16.5) exhibits parallel outflow tracts and is diagnosed with DORV and ventricular non-compaction by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
EFIC SummaryMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Serial 2D EFIC image stack in the coronal plane of 2437-005-3 (E16.5) reveals DORV with a non-committed VSD, and venticular non-compaction
Click thumbnail to play movie.		Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Color flow spectral Doppler imaging of mutant 2437-005-003 (E16.5) in the sagittal view shows two great arteries originating from RV primarily, suggesting DORV
Click thumbnail to play movie.		Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-3 (E16.5) presents with exencephaly and micrognathiaMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-3 (E16.5) shows exencephaly and cleft lipMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) presents with exencephalyMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) shows exencephaly and facial clefting or cleft lipMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) has interrupted aortic arch and non-compaction of the ventricles which is confimed by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-006-1 (E16.5) exhibits an interrupted aortic arch and abnormal positioning of the outflows that is diagnosed as overriding aorta by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
EFIC SummaryMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Serial 2D EFIC image stack in the coronal plane of 2437-006-1 (E16.5) reveals an overriding aorta, AVSD, interrupted aortic arch (type B), and ventricular non-compaction
Click thumbnail to play movie.		Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Color flow spectral Doppler imaging of mutant 2437-006-1 (E16.5) in the sagittal view shows the two great arteries originating from RV predominantly, suggesting overriding aorta
Click thumbnail to play movie.		Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Color flow spectral Doppler imaging of mutant 2437-006-1 (E16.5) in the transverse view shows shunting between LV and RV, suggesting atrioventricular septal defect (AVSD)
Click thumbnail to play movie.		Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) exhibited exencehpaly and was found deadMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) presents with cleft lip and micrognathiaMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) shows abnormal patterning on ventricles which indicates ventricular non-compaction and is confirmed by EFIC imagingMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Mutant 2437-005-2 (E16.5) shows malalignment of the great arteries, which EFIC imaging shows is DORVMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
EFIC SummaryMyh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Serial 2D EFIC image stack in the coronal plane of 2437-005-2 (E16.5) reveals DORV, AVSD, and ventricular non-compaction
Click thumbnail to play movie.		Myh10b2b2437Clo/Myh10b2b2437CloC57BL/6J-Myh10b2b2437Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory