| Mutant 2445-007-NA has parallel outflow tracts that was later confirmed as DORV by EFIC imaging | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| EFIC Summary | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Serial EFIC image stack of 2445-007-NA in the coronal plane reveals DORV, subaortic VSD, and biventricular hypertrophy Click thumbnail to play movie. | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-NA presents with spina bifida | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-NA exhibits a shortened body, short snout, micrognathia, and cryptophthalmos | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-NA exhibits left duplex kidney, hydronephrosis and the presence of cysts as seen by histology | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| The left kidney of 2445-007-NA shows hydronephrosis and the presence of cysts | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-003-1 (E16.5) presents with excencephaly, omphalocele, and a short trunk | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-003-1 (E16.5) presents with spina bifida and no tail | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-003-1 (E16.5) exhibits polydactyly on right hindlimb | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-003-1 (E16.5) exhibits malaligned great arteries and abnormal aortic arch, which was confirmed as DORV and hypoplastic transverse aorta by EFIC imaging | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-003-1 (E16.5) has cystic kidneys as seen on histology | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| EFIC Summary | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Serial 2D EFIC image stack in the coronal plane of 2445-003-1 (E16.5) reveals DORV, subaortic VSD, mVSD, and hypoplastic transverse aorta Click thumbnail to play movie. | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Color flow spectral Doppler imaging of mutant 2445-003-1 (E16.5) in the sagittal view shows two great arteries originating from RV primarily, suggesting DORV Click thumbnail to play movie. | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| The kidneys of 2445-003-1 have mild cystic kidney disease | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-2 (E17.5) presents with excencephaly, short snout, micrognathia, and no tail | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-2 (E17.5) shows spina bifida | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-2 (E17.5) exhibits a maligned sternal vertebra | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Left kidney of 2445-007-2 has mild cysts or cystic dilations of the tubules | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2554-007-1 (E17.5) exhibits excencephaly, anophthalmia of the right eye, micrognathia, microstomia, a short snout, and preaxial digit duplication of the right hindlimb | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-1 (E17.5) shows spina bifida, no tail, and exencephaly | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-1 (E!7.5) presents with a maligned sternal vertebra | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |
| Mutant 2445-007-1 (E17.5) shows malaligned great arteries | Ptk7b2b2445Clo/Ptk7b2b2445Clo | C57BL/6J-Ptk7b2b2445Clo |