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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ptk7b2b2445Clo
Name: PTK7 protein tyrosine kinase 7; Bench to Bassinet Program (B2B/CVDC), mutation 2445 Cecilia Lo
MGI ID: MGI:5552948
Synonyms: Herky
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2445-007-NA has parallel outflow tracts that was later confirmed as DORV by EFIC imagingPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
EFIC SummaryPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Serial EFIC image stack of 2445-007-NA in the coronal plane reveals DORV, subaortic VSD, and biventricular hypertrophy
Click thumbnail to play movie.		Ptk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-NA presents with spina bifidaPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-NA exhibits a shortened body, short snout, micrognathia, and cryptophthalmosPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-NA exhibits left duplex kidney, hydronephrosis and the presence of cysts as seen by histologyPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
The left kidney of 2445-007-NA shows hydronephrosis and the presence of cystsPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-003-1 (E16.5) presents with excencephaly, omphalocele, and a short trunkPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-003-1 (E16.5) presents with spina bifida and no tailPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-003-1 (E16.5) exhibits polydactyly on right hindlimbPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-003-1 (E16.5) exhibits malaligned great arteries and abnormal aortic arch, which was confirmed as DORV and hypoplastic transverse aorta by EFIC imagingPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-003-1 (E16.5) has cystic kidneys as seen on histologyPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
EFIC SummaryPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Serial 2D EFIC image stack in the coronal plane of 2445-003-1 (E16.5) reveals DORV, subaortic VSD, mVSD, and hypoplastic transverse aorta
Click thumbnail to play movie.		Ptk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Color flow spectral Doppler imaging of mutant 2445-003-1 (E16.5) in the sagittal view shows two great arteries originating from RV primarily, suggesting DORV
Click thumbnail to play movie.		Ptk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
The kidneys of 2445-003-1 have mild cystic kidney diseasePtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-2 (E17.5) presents with excencephaly, short snout, micrognathia, and no tailPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-2 (E17.5) shows spina bifidaPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-2 (E17.5) exhibits a maligned sternal vertebraPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Left kidney of 2445-007-2 has mild cysts or cystic dilations of the tubulesPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2554-007-1 (E17.5) exhibits excencephaly, anophthalmia of the right eye, micrognathia, microstomia, a short snout, and preaxial digit duplication of the right hindlimbPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-1 (E17.5) shows spina bifida, no tail, and exencephalyPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-1 (E!7.5) presents with a maligned sternal vertebraPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Mutant 2445-007-1 (E17.5) shows malaligned great arteriesPtk7b2b2445Clo/Ptk7b2b2445CloC57BL/6J-Ptk7b2b2445Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory