Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Mapk7^b2b2346Clo
Name:	mitogen-activated protein kinase 7; Bench to Bassinet Program (B2B/CVDC), mutation 2346 Cecilia Lo
MGI ID:	MGI:5554435
Synonyms:	Smiley

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2346-004-2 (E16.5) exhibits parallel outflow tracts, hypoplastic transverse arch, and thin ventricles which is diagnosed as DORV and ventricular non-compaction by EFIC imaging	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Color flow spectral Doppler imaging in the sagittal view of mutant 2346-004-2 (E16.5) shows the two great arteries predominantly originating from the RV, which suggests DORV. This was confirmed by EFIC imaging Click thumbnail to play movie.	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	EFIC Summary	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Serial 2D EFIC image stack in the coronal plane of 2346-004-2 (E16.5) reveals DORV, subaortic VSD, hypoplastic transverse aorta, and ventricular non-compaction Click thumbnail to play movie.	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Mutant 2346-004-2 (E16.5) shows hypoplastic kidneys with hydronephrosis	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Mutant 2346-004-1 (E16.5) was found dead and showed developmentally delay with parallel outflow tracts, and thin ventricles, subsequently shown to be DORV and ventricular non-compaction by EFIC imaging	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	EFIC Summary	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Serial 2D EFIC image stack in the coronal plane of 2346-004-1 (E16.5) shows developmental delay, DORV, AVSD, and ventricular non-compaction Click thumbnail to play movie.	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Mutant 2346-004-3 (E16.5) shows a narrow ductus arteriosus	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	EFIC Summary	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Serial 2D EFIC image stack in the coronal plane of 2346-004-3 (E16.5) shows pmVSD, mVSD, narrow DA Click thumbnail to play movie.	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Mutant 2346-004-3 (E16.5) has cystic kidneys, hydronephrosis, and hydroureter	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	The kidneys of 2346-004-3 have hydronephrosis	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo
	Kidneys of 2346-004-3 have cystic tubules and glomeruli. The left kidney shows a hydroureter; the right kidney shows hydronephrosis	\Mapk7^b2b2346Clo/\Mapk7^b2b2346Clo	C57BL/6J-Mapk7^b2b2346Clo

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