Phenotype Images associated with this Allele

Nomenclature

Symbol:	Mmp21^b2b2458Clo
Name:	matrix metallopeptidase 21; Bench to Bassinet Program (B2B/CVDC), mutation 2458 Cecilia Lo
MGI ID:	MGI:5554438
Synonyms:	c.T973A, Koli, p.Tyr325Asn

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2458-002-LA exhibits heterotaxy with levocardia, right lung isomerism (3R/3L), dextrogastria, and interrupted aortic arch which is confirmed by EFIC imaging	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	EFIC Summary	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Serial 2D EFIC image stack in the coronal plane of 2458-002-LA shows TGA {A,D,D}, unbalanced AVSD, common atrium, hypoplastic RV, interrupted aortic arch (type B), and right lung isomerism Click thumbnail to play movie.	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-002-LA shows immotile cilia Click thumbnail to play movie.	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-002-LA exhibits heterotaxy with right lung isomerism (3R/3L) and hypoplastic LV	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-002-LA presents with interrupted and anterior aortic arch which is also seen by EFIC imaging and is diagnosed with TGA	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-004-NB shows micrognathia	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-004-NB presents with a malaligned sternum	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-004-NB exhibits heterotaxy with dextrocardia, right lung isomerism (3R/4L), dextrogastria, and anterior aorta which is confirmed to be TGA by EFIC imaging	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-004-NB has dextrocardia with left aortic arch and the aorta anterior, which was diagnosed as TGA by EFIC imaging	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	EFIC Summary	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Serial 2D EFIC image stack in the coronal plane of 2458-004-NB shows dextrocardia, TGA {A,L,L}, AVSD, left aortic arch, mLV hypertrophy, and right lung isomerism Click thumbnail to play movie.	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-004-2 (E16.5) is diagnosed with heterotaxy with dextrocardia, dextrogastria, parallel outflow tracts and a thin mRV which is confirmed to be DORV and mRV non-compaction as seen by EFIC imaging	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	EFIC Summary	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Serial 2D EFIC image stack in the coronal plane of 2458-004-2 (E16.5) shows dextrocardia {A,L,L}, DORV, non-committed VSD, spongy mRV, dual IVC, pulmonary vein connected to RA, and right lung isomerism Click thumbnail to play movie.	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-002-NC presents with micrognathia	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-002-NC exhibits heterotaxy with right lung isomerism (3R/3L)	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-002-NC presents with anterior aorta and malpositioned outflow which is diagnosed as Taussig-Bing type DORV by EFIC imaging	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	EFIC Summary	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Serial 2D EFIC image stack in the coronal plane of 2458-002-NC shows Taussig-Bing type DORV, AVSD {S,D,D}, and right lung isomerism Click thumbnail to play movie.	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Mutant 2458-004-3 (E16.5) exhibits heterotaxy with levocardia and right lung isomerism (3R/3L)	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	EFIC Summary	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo
	Serial 2D EFIC image stack in the coronal plane of 2458-004-3 (E16.5) shows DORV, AVSD, mVSD, and right lung isomerism Click thumbnail to play movie.	Mmp21^b2b2458Clo/Mmp21^b2b2458Clo	C57BL/6J-Mmp21^b2b2458Clo

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