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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ccdc39b2b2025.1Clo
Name: coiled-coil domain containing 39; Bench to Bassinet Program (B2B/CVDC) mutation 2025, subline 1, Cecilia Lo
MGI ID: MGI:5554444
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2025-003-LA exhibits heterotaxy with dextrocardia, left aortic arch (LAA), and transposition of the great arteries (TGA)b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-003-LA shows heterotaxy with dextrocardia with transposition of the great arteries (TGA), left liver isomerism (2R/2L), and normal lung lobation (3R/2L)b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
EFIC Summaryb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Serial 2D EFIC image stack in the coronal plane of 2025-003-LA shows dextrocardia, TGA and AVSD {I,L,L}
Click thumbnail to play movie.		b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-003-LA shows heterotaxy with dextrogastriab2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-003-LA has immotile tracheal airway cilia
Click thumbnail to play movie.		b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-005-1 (E14.5) exhibits abnormally positioned heart with superior-inferior positioning of ventriclesb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-005-1 (E14.5) exhibits heterotaxy with mesocardia and dextrogastriab2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
EFIC Summaryb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Serial 2D EFIC image stack in the coronal plane of 2025-005-1 (E14.5) shows superior inferior ventricles, DORV, AVSD, mVSD, RAA, aberrant left subclavian artery forming incomplete vascular ring, dual IVC, and right atrial isomerism
Click thumbnail to play movie.		b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Color flow spectral Doppler penetration is not very good. Imaging of mutant 2025-005-1 (E14.5) in the sagittal view shows two great arteries originating from RV primarily, suggesting DORV
Click thumbnail to play movie.		b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-003-1 (E15.5) exhibits levocardia with malalignment of the great arteries with abnormal aortic arch shown by EFIC histology to comprise of an interruption between right brachiocephalic artery and left carotid artery with neck artery branching pattern remaining left sided. Also diagnosed as non-compaction by EFIC.b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-003-1 (E15.5) exhibits heterotaxy with levocardia and dextrogastriab2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-003-1 (E15.5) exhibits heterotaxy with dextrogastria, right-sided pancreas, and aspleniab2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
EFIC Summaryb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Serial EFIC image stack in coronal plane of mutant 2025-003-1 (E15.5) shows DORV, unbalanced AVSD {S,D,D}, IAA (type C), bicuspid aortic valve, small LV, ventricular non-compaction, and left atrial isomerism
Click thumbnail to play movie.		b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-005-3 (E14.5) is diagnosed with heterotaxy with dextroversion, left lung isomerism (1R/1L) and overriding aorta which is confirmed by EFICb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
EFIC Summaryb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Serial 2D EFIC image stack in the coronal plane of 2025-005-3 (E14.5) shows AVSD, mVSD, incomplete vascular ring, azygous venous connection, right and left hepatic vein connection to atrium (A,D,D}, and left lung isomerism
Click thumbnail to play movie.		b2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Mutant 2025-005-3 (E14.5) exhibits heterotaxy with dextroversion and hypoplastic thymusb2b2025Clo/b2b2025CloC57BL/6J-b2b2025Clo
Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1CloC57BL/6J-Ccdc39b2b2025.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory