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Phenotype Images associated with this Allele
Nomenclature
Symbol: Elp1tm1c(KOMP)Wtsi
Name: elongator complex protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5558022
Synonyms: IkbkapLoxP
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Reduced numbers of sympathetic and dorsal root ganglia neurons in Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 fetusesElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 fetuses exhibit a decreased inferior facial angle and increased mandibular retropositionElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Reduction in the number of TH+ neurons in the dorsal root ganglia of Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 embryosElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Reduction in the number of TrkA+ fibers in the dorsal horn of the spinal cord and in the skin of Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)WtsiH2az2Tg(Wnt1-cre)11Rth/0 fetusesElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Reduced sympathetic and parasympathetic innervation of the submandibular gland in Elp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi H2az2Tg(Wnt1-cre)11Rth/0 embryosElp1tm1c(KOMP)Wtsi/Elp1tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+		involves: C57BL/6J * C57BL/6N * CBA/J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory