Phenotype Images associated with this Allele

Nomenclature

Symbol:	Adamts6^b2b2407Clo
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2407 Cecilia Lo
MGI ID:	MGI:5560143
Synonyms:	Rory

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2407-003-4 (E16.5) exhibits malalignment of the great arteries, which is confirmed by EFIC imaging as overridng aorta, a hypoplastic transverse arch and possible ventricular non-compaction	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack in the coronal plane of 2407-003-4 (E16.5) reveals overriding aorta, pmVSD, and ventricular non-compaction suspected Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) presents with a short snout, abnormally attached hindlimbs, and slight hydrops	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) exhibits a cleft palate	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) presents with an unfused sternum	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) shows hypoplastic thymus	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow Doppler imaging in the sagittal view of mutant 2407-003-4 (E16.5) shows a VSD and both great arteries originating from RV with aliasing in Ao, which suggests DORV	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow Doppler imaging in the sagittal view of mutant 2407-003-4 (E16.5) shows a VSD and both great arteries originating from RV with regurgitation of Ao and PA, which suggests DORV	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Spectral Doppler imaging of mutant 2407-003-4 (E16.5) confirms that the aliasing in Ao is aortic stenosis with regurgitation	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow Doppler imaging in the transverse view of mutant 2407-003-4 (E16.5) shows a VSD	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-3 (E16.5) exhibits a short snout and abnormally attached hindlimbs	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-3 (E16.5) has a cleft palate	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-3 (E16.5) shows malalignment of the great arteries, which is diagnosed as overriding aorta by EFIC imaging	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack in the coronal plane of 2407-003-3 (E16.5) reveals overriding aorta, pmVSD, and ventricular non-compaction suspected Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow spectral Doppler imaging of mutant 2407-003-3 (E16.5) in the sagittal view shows aorta overriding over septum Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-1 (E16.5) presents with a cleft palate	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-1 (E16.5) has a hypoplastic thymus	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-1 (E16.5) is diagnosed with DORV and hypoplastic PA by EFIC imaging	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack in the coronal plane of 2407-003-1 (E16.5) shows DORV, AVSD, hypoplastic PA, and ventricular non-compaction Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-005-NB exhibits abnormally attached hindlimbs, short snout, and micrognathia	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-005-NB shows an unfused sternum	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-005-NB has parallel outflow tracts which is diagnosed as overriding aorta by EFIC imaging	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack of 2407-005-NB in the coronal plane reveals an overriding aorta and pmVSD Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24