Phenotype Images associated with this Allele

Nomenclature

Symbol:	Adamts6^b2b2407Clo
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2407 Cecilia Lo
MGI ID:	MGI:5560143
Synonyms:	Rory

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2407-003-4 (E16.5) exhibits malalignment of the great arteries, which is confirmed by EFIC imaging as overridng aorta, a hypoplastic transverse arch and possible ventricular non-compaction	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack in the coronal plane of 2407-003-4 (E16.5) reveals overriding aorta, pmVSD, and ventricular non-compaction suspected Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) presents with a short snout, abnormally attached hindlimbs, and slight hydrops	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) exhibits a cleft palate	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) presents with an unfused sternum	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-4 (E16.5) shows hypoplastic thymus	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow Doppler imaging in the sagittal view of mutant 2407-003-4 (E16.5) shows a VSD and both great arteries originating from RV with aliasing in Ao, which suggests DORV	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow Doppler imaging in the sagittal view of mutant 2407-003-4 (E16.5) shows a VSD and both great arteries originating from RV with regurgitation of Ao and PA, which suggests DORV	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Spectral Doppler imaging of mutant 2407-003-4 (E16.5) confirms that the aliasing in Ao is aortic stenosis with regurgitation	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow Doppler imaging in the transverse view of mutant 2407-003-4 (E16.5) shows a VSD	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-3 (E16.5) exhibits a short snout and abnormally attached hindlimbs	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-3 (E16.5) has a cleft palate	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-3 (E16.5) shows malalignment of the great arteries, which is diagnosed as overriding aorta by EFIC imaging	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack in the coronal plane of 2407-003-3 (E16.5) reveals overriding aorta, pmVSD, and ventricular non-compaction suspected Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Color flow spectral Doppler imaging of mutant 2407-003-3 (E16.5) in the sagittal view shows aorta overriding over septum Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-1 (E16.5) presents with a cleft palate	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-1 (E16.5) has a hypoplastic thymus	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-003-1 (E16.5) is diagnosed with DORV and hypoplastic PA by EFIC imaging	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack in the coronal plane of 2407-003-1 (E16.5) shows DORV, AVSD, hypoplastic PA, and ventricular non-compaction Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-005-NB exhibits abnormally attached hindlimbs, short snout, and micrognathia	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-005-NB shows an unfused sternum	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Mutant 2407-005-NB has parallel outflow tracts which is diagnosed as overriding aorta by EFIC imaging	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	EFIC Summary	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo
	Serial 2D EFIC image stack of 2407-005-NB in the coronal plane reveals an overriding aorta and pmVSD Click thumbnail to play movie.	Adamts6^b2b2407Clo/Adamts6^b2b2407Clo	C57BL/6J-Adamts6^b2b2407Clo

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