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Phenotype Images associated with this Allele
Nomenclature
Symbol: Slit3b2b2362.1Clo
Name: slit guidance ligand 3; Bench to Bassinet Program (B2B/CVDC) mutation 2362, subline 1, Cecilia Lo
MGI ID: MGI:5560156
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2362-004-1 (E16.5) exhibits ectopia cordis, ventricular non-compaction, and gastroschisis with a body wall closure defectb2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Mutant 2362-004-1 (E16.5) with ectopia cortis exhibits DORV with aorta positioned anteriorly (Taussig Bing subtype DORV), which was confirmed by EFIC histologyb2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
EFIC Summaryb2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Serial 2D EFIC image stack in the coronal plane of 2362-004-1 (E16.5) reveals Taussig-Bing type DORV, AVSD, and ventricular non-compaction
Click thumbnail to play movie.		b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Ultrasound imaging of mutant 2362-004 (E16.5) in the sagittal view shows the heart out of the chest, suggesting ectopia cordis
Click thumbnail to play movie.		b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Mutant embryo at E16.5 show abnormal severely hypoplastic kidney.b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Mutant 2362-004-2 (E16.5) was diagnosed as having DORV by fetal echocardiography, later confirmed by EFIC histologyb2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
EFIC Summaryb2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Serial 2D EFIC image stack in the coronal plane of 2362-004-2 (E16.5) reveals DORV and a subaortic VSD
Click thumbnail to play movie.		b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Mutant embryo (E16.5) has a few glomerular cysts.b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Mutant has hypoplastic kidneys with glomerular cysts.b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Mutant has hypoplastic kidneys with glomerular cysts.b2b2362Clo/b2b2362CloC57BL/6J-b2b2362Clo
Slit3b2b2362.1Clo/Slit3b2b2362.1CloC57BL/6J-Slit3b2b2362.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory