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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ift140b2b1283Clo
Name: intraflagellar transport 140; Bench to Bassinet Program (B2B/CVDC), mutation 1283 Cecilia Lo
MGI ID: MGI:5560263
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1283-007-NA exhibits abnormal arrangement of the outflow tracts with the aorta anterior, RAA, and thickened ventricular wall. Sample is diagnosed with PTA and biventricular hypertrophy by EFIC imagingIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
EFIC SummaryIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Serial 2D EFIC image stack in the coronal plane of 1283-007-NA reveals PTA (type A2), AVSD, RAA, and biventricular hypertrophy
Click thumbnail to play movie.		Ift140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-007-NA presents with left kidney agenesis, hydronephrosis of the right kidney, and cystic kidney which is confirmed by histologyIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Right kidney of mutant 1283-007-NA is hydronephrotic and has hydroureter. Some cysts are presentIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-003-2 (E16.5) presents with a cleft palateIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-003-2 (E16.5) presents with left lung isomerism, normal outflow, and thickened ventricular wall which is diagnosed as biventricular hypertrophy by EFIC imagingIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-003-2 (E16.5) shows heterotaxy with malrotated gut, left-sided stomach, midline pancreas, and aspleniaIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
EFIC SummaryIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Serial 2D EFIC image stack in the coronal plane of 1283-003-2 (E16.5) reveals AVSD, and LV hypertrophy
Click thumbnail to play movie.		Ift140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-003-2 (E16.5) exhibits cystic kidneys which is confirmed by histology imagingIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Ureteric bud of mutant 1293-003-2 has short ciliaIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-003-2 has cystic tubules and glomeruliIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Glomerui and tubules of kidneys of mutant 1283-003-2 are cystic (right kidney shown)Ift140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Mutant 1283-003-2 (E16.5) exhibits preaxial digit duplicationIft140b2b1283Clo/Ift140b2b1283CloC57BL/6J-Ift140b2b1283Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory