Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Bmpr2^b2b2556Clo
Name:	bone morphogenetic protein receptor type 2; Bench to Bassinet Program (B2B/CVDC) mutation 2556, Cecilia Lo
MGI ID:	MGI:5560496

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2556-004-1 (E16.5) exhibits parallel outflow tracts and ventricles appear thin which is diagnosed as PTA (Type A4) and ventricular non-copmaction by EFIC imaging and the heart is malrotated further to the left	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	EFIC Summary	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	Serial 2D EFIC image stack in the coronal plane of 2556-004-1 (E16.5) reveals PTA (Type A4), no OFT valves, AVSD, and ventricular myocardial non-compaction Click thumbnail to play movie.	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	Color flow spectral Doppler imaging of mutant 2556-004-1 (E15.5) in the sagittal view shows only one thick great artery can be detected originating from the heart and severe regurgitation. These together suggest PTA. Click thumbnail to play movie.	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	Mutant 2556-004-1 (E16.5) presents with hydronephrosis	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	Mutant 2556-004-6 (E16.5) shows an enlarged pulmonary, the heart is slightly malrotated to the left, and RV appears to have a thin wall which is diagnosed as incomplete separation of the outflow tracts and ventricular non-compaction by EFIC imaging	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	EFIC Summary	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	Serial 2D EFIC image stack in the coronal plane of 2556-004-6 (E16.5) reveals incomplete great artery septation at proximal region, ventricular septation, no PA valves, PDA, large interventricular foramen, and ventricular myocardial non-compaction Click thumbnail to play movie.	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo
	Mutant 2556-004-6 (16.5) presents with hydronephrosis	Bmpr2^b2b2556Clo/Bmpr2^b2b2556Clo	C57BL/6J-Bmpr2^b2b2556Clo

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