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Phenotype Images associated with this Allele
Nomenclature
Symbol: Lrp2b2b2671Clo
Name: low density lipoprotein receptor-related protein 2; Bench to Bassinet Program (B2B/CVDC), mutation 2671 Cecilia Lo
MGI ID: MGI:5560499
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2671-006-3 (E16.5) exhibits PTA with a RAA and thin ventricle wall which is confirmed by EFIC imaging as ventricular non-compactionLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-006-3 (E16.5) shows PTA (Type A1), RAA, muscular VSD, and ventricular myocardial non-compaction
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Color Flow Spectral Doppler Imaging of mutant 2671-006-003 (E16.5) in the sagittal view shows only one thick great artery originating from the RV with regurgitation. These together suggest PTA
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-3 (E16.5) is runted, has hydrops, anophthalmia of the right eye, and short snoutLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-3 (E16.5) has microphthalmia of the left eye and an incomplete closure of the umbilical herniationLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) is diagnosed with PTA and biventricular hypertrophy that is confirmed by EFIC imagingLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-002-2 (E17.5) shows PTA (Type A2), and biventricular hypertrophy
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) presents with anophthalmia, micrognathia, and short snoutLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) presents with a hypoplastic thymusLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) shows hydronephrosis and possibly cystic kidneysLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) has PTA which is confirmed by EFIC imagingLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-002-1 (E17.5) shows PTA (Type A4), and biventricular hypertrophy
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) exhibits anophthalmia, micrognathia, and short snoutLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) presents with a hooked tailLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) has a hypoplastic thymusLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) present with hydronephrosis and possibly cystic kidneysLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-2 (E16.5) exhibits suspected PTA and RAA which is confirmed by EFIC imagingLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-006-2 (E16.5) shows PTA (Type A2), RAA, and an aberrant left subclavian artery forming incomplete vascular ring
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-2 (E16.5) is runted, has hydrops, anophthalmia, short snout, and incomplete closure of the umbilical herniationLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
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