About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Lrp2b2b2671Clo
Name: low density lipoprotein receptor-related protein 2; Bench to Bassinet Program (B2B/CVDC), mutation 2671 Cecilia Lo
MGI ID: MGI:5560499
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2671-006-3 (E16.5) exhibits PTA with a RAA and thin ventricle wall which is confirmed by EFIC imaging as ventricular non-compactionLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-006-3 (E16.5) shows PTA (Type A1), RAA, muscular VSD, and ventricular myocardial non-compaction
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Color Flow Spectral Doppler Imaging of mutant 2671-006-003 (E16.5) in the sagittal view shows only one thick great artery originating from the RV with regurgitation. These together suggest PTA
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-3 (E16.5) is runted, has hydrops, anophthalmia of the right eye, and short snoutLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-3 (E16.5) has microphthalmia of the left eye and an incomplete closure of the umbilical herniationLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) is diagnosed with PTA and biventricular hypertrophy that is confirmed by EFIC imagingLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-002-2 (E17.5) shows PTA (Type A2), and biventricular hypertrophy
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) presents with anophthalmia, micrognathia, and short snoutLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) presents with a hypoplastic thymusLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-2 (E17.5) shows hydronephrosis and possibly cystic kidneysLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) has PTA which is confirmed by EFIC imagingLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-002-1 (E17.5) shows PTA (Type A4), and biventricular hypertrophy
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) exhibits anophthalmia, micrognathia, and short snoutLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) presents with a hooked tailLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) has a hypoplastic thymusLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-002-1 (E17.5) present with hydronephrosis and possibly cystic kidneysLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-2 (E16.5) exhibits suspected PTA and RAA which is confirmed by EFIC imagingLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
EFIC SummaryLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Serial 2D EFIC image stack in the coronal plane of mutant 2671-006-2 (E16.5) shows PTA (Type A2), RAA, and an aberrant left subclavian artery forming incomplete vascular ring
Click thumbnail to play movie.		Lrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Mutant 2671-006-2 (E16.5) is runted, has hydrops, anophthalmia, short snout, and incomplete closure of the umbilical herniationLrp2b2b2671Clo/Lrp2b2b2671CloC57BL/6J-Lrp2b2b2671Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory