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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2736Clo
Name: Mutant line 2736; Bench to Bassinet Program (B2B/CVDC), mutation 2736 Cecilia Lo
MGI ID: MGI:5560813
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2736-005-LA shows heterotaxy with dextrocardia, right pulmonary isomerism (4R/4L), and left liver isomerism (2R/2L)b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-005-LA exhibits heterotaxy with dextroversion, and right lung isomerism (4R/4L). Aorta is anterior and ventricles are mispositioned which is diagnosed as TGA and superior-inferior ventricles by EFIC imagingb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
EFIC Summaryb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Serial 2D EFIC image stack of 2736-005-LA in the coronal plane reveals dextroversion, superior-inferior ventricles, TGA {A,D,D}, unbalanced AVSD, common atrium, small RV, muscular VSD, and right lung isomerism
Click thumbnail to play movie.		b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-005-LA presents with polyspleniab2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-005-LA shows heterotaxy with a malrotated gut and midline pancreas and stomachb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-004-LA presents with a malaligned sternal vertebrab2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-004-LA exhibits heterotaxy with mesocardia and right lung isosmerism (3R/3L)b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-004-LA is diagnosed with TGA by EFIC imagingb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-004-LA exhibits dextrogastria with a right-sided stomach, pancreas, and spleenb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
EFIC Summaryb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Serial 2D EFIC image stack of 2736-004-LA in the coronal plane reveals mesocardia, TGA {A,D,D}, AVSD, and right lung isomerism
Click thumbnail to play movie.		b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-003-LA presents with a malaligned sternal vertebrab2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-003-LA presents with heterotaxy: levocardia, dextrogastria, and malrotated intestinesb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-003-LA exhibits heterotaxy with right lung isomerism (3R/3L) and left liver isomerism (2R/2L)b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-003-LA shows abnormal placement of the outflow tracts, with the aorta slightly anterior and dual IVC which is diagnosed as TGA with dual IVC by EFIC imagingb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
EFIC Summaryb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Serial 2D EFIC image stack of 2736-003-LA in the coronal plane reveals TGA {A,D,D}, AVSD, right atrial isomerism (symmetric SVC connection), right IVC and left hepatic vein connection, and right lung isomerism
Click thumbnail to play movie.		b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-003-LA exhibits heterotaxy with right lung isomerism (3R/3L)b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-005-LI exhibits heterotaxy with levocardia, right lung isomerism (3R/3L) and dextrogastriab2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-005-LI presents with hypoplastic transverse aortic arch and parallel outflow tracts, diagnosed as TGA by EFIC imagingb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-005-LI exhibits heterotaxy with dextrogastria and a hypoplastic spleenb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
EFIC Summaryb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Serial 2D EFIC image stack of 2736-005-LI in the coronal plane reveals TGA {S(A),D,D}, AVSD, TAPVR (intracardiac type), right lung isomerism with right isomerism bronchial branching pattern
Click thumbnail to play movie.		b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
EFIC Summaryb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Serial 2D EFIC image stack of 2736-003-NA in the coronal plane reveals dextroversion {A,D,D}, TGA, unbalanced AVSD, bilateral PDAs forming vascular ring, left aortic arch, aberrant right subclavian artery, and right lung isomerism
Click thumbnail to play movie.		b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
Cfc1b2b2736.1Clo/Cfc1b2b2736.1CloC57BL/6J-Cfc1b2b2736.1Clo
Mutant 2736-002-1 (E14.5) exhibits apparent absence of the pulmonary artery with right aortic arch, confirmed as persistent truncus arterioles (PTA) by EFIC imagingb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
b2b2736.2Clo/b2b2736.2CloC57BL/6J-b2b2736.2Clo
EFIC Summaryb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
b2b2736.2Clo/b2b2736.2CloC57BL/6J-b2b2736.2Clo
Serial 2D EFIC image stack of 2736-002-1 (E14.5) in the coronal plane reveals PTA (Type 1), AVSD, right aortic arch, aberrant left subclavian artery forming vascular ring
Click thumbnail to play movie.		b2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
b2b2736.2Clo/b2b2736.2CloC57BL/6J-b2b2736.2Clo
Mutant 1736-002-1 (E14.5) is rusted and presents with oligodactyly, hydrops, micrognathia, and microphthalmia of the right eyeb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
b2b2736.2Clo/b2b2736.2CloC57BL/6J-b2b2736.2Clo
Mutant 2736-002-1 (E14.5) exhibits hypoplastic thymus and hypoplastic lungsb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
b2b2736.2Clo/b2b2736.2CloC57BL/6J-b2b2736.2Clo
Mutant 2736-002-1 (E14.5) shows cleft palateb2b2736Clo/b2b2736CloC57BL/6J-b2b2736Clo
b2b2736.2Clo/b2b2736.2CloC57BL/6J-b2b2736.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory