Phenotype Images associated with this Allele
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Nomenclature
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Symbol:
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b2b2140Clo
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Name:
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Mutant line 2140;
Bench to Bassinet Program (B2B/CVDC), mutation 2140 Cecilia Lo
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MGI ID:
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MGI:5560901
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Images for
Allele
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Click images for details
 | Mutant 2140-006-2 (E15.5) show heterotaxy with dextroversion, PTA, and a right aortic arch | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | EFIC Summary | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Serial 2D EFIC image stack in the coronal plane of 2140-006-2 (E15.5) shows PTA (Type A-1), AVSD, right aortic arch, vascular ring, and dextroversion
Click thumbnail to play movie. | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Color flow spectral Doppler imaging of mutant 2140-006-2 (E15.5) in the sagittal view shows only one large great artery originating from the bottom of heart, suggesting PTA
Click thumbnail to play movie. | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Color flow spectral Doppler imaging of mutant 2140-006-2 (E15.5) in the transverse view shows shunting between LV and RV, suggesting AVSD or VSD | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-2 (E15.5) presents with central polydactyly, preaxial digit duplication, and syndactyly | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-2 (E15.5) has hypoplastic kidneys and misplaced gonads | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-2 (E15.5) has a hypoplastic spleen | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-1 (E15.5) has parallel outflow tracts, pulmonary stenosis, thickened ventricular walls, and hypoplastic lungs. Diagnosed with DORV, hypoplastic PA, and biventricular hypertrophy by EFIC imaging | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | EFIC Summary | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Serial 2D EFIC image stack of 2140-006-1 (E15.5) in the coronal plane shows DORV, AVSD, hypoplastic PA (TOF), dilated aorta, coronary fistula, biventricular hypertrophy, right diaphragmatic herniation (Bockdalek type)
Click thumbnail to play movie. | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-1 (E15.5) has hypoplastic kidneys and misplaced gonads | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-1 (E15.5) has a hypoplastic spleen | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-1 (E15.5) has central polydactyly, preaxial digit duplication, and syndactyly | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
 | Mutant 2140-006-1 has glomerular cysts | b2b2140Clo/b2b2140Clo | C57BL/6J-b2b2140Clo |
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