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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2140Clo
Name: Mutant line 2140; Bench to Bassinet Program (B2B/CVDC), mutation 2140 Cecilia Lo
MGI ID: MGI:5560901
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2140-006-2 (E15.5) show heterotaxy with dextroversion, PTA, and a right aortic archb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
EFIC Summaryb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Serial 2D EFIC image stack in the coronal plane of 2140-006-2 (E15.5) shows PTA (Type A-1), AVSD, right aortic arch, vascular ring, and dextroversion
Click thumbnail to play movie.		b2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Color flow spectral Doppler imaging of mutant 2140-006-2 (E15.5) in the sagittal view shows only one large great artery originating from the bottom of heart, suggesting PTA
Click thumbnail to play movie.		b2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Color flow spectral Doppler imaging of mutant 2140-006-2 (E15.5) in the transverse view shows shunting between LV and RV, suggesting AVSD or VSDb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-2 (E15.5) presents with central polydactyly, preaxial digit duplication, and syndactylyb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-2 (E15.5) has hypoplastic kidneys and misplaced gonadsb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-2 (E15.5) has a hypoplastic spleenb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-1 (E15.5) has parallel outflow tracts, pulmonary stenosis, thickened ventricular walls, and hypoplastic lungs. Diagnosed with DORV, hypoplastic PA, and biventricular hypertrophy by EFIC imagingb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
EFIC Summaryb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Serial 2D EFIC image stack of 2140-006-1 (E15.5) in the coronal plane shows DORV, AVSD, hypoplastic PA (TOF), dilated aorta, coronary fistula, biventricular hypertrophy, right diaphragmatic herniation (Bockdalek type)
Click thumbnail to play movie.		b2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-1 (E15.5) has hypoplastic kidneys and misplaced gonadsb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-1 (E15.5) has a hypoplastic spleenb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-1 (E15.5) has central polydactyly, preaxial digit duplication, and syndactylyb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Mutant 2140-006-1 has glomerular cystsb2b2140Clo/b2b2140CloC57BL/6J-b2b2140Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory