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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2739Clo
Name: Mutant line 2739; Bench to Bassinet Program (B2B/CVDC), mutation 2739 Cecilia Lo
MGI ID: MGI:5560910
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2739-005-1 (E15.5) shows abnormal arrangement of the great arteries and thin ventricular walls which is diagnosed as DORV and ventricular non-compaction by EFIC imagingb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
EFIC Summaryb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Serial 2D EFIC image stack of 2739-005-1 (E15.5) in the coronal section reveals DORV {S,D,D}, AVSD, ventricular non-compaction, cushion-like atrioventricular valve and semilunar valves
Click thumbnail to play movie.
b2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Mutant 2739-005-1 (E15.5) is runted with patechiae, hydrops, anophthalmia, and craniofacial defects with micrognathiab2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Mutant 2739-005-1 (E15.5) exhibits cleft lip and cleft palate associated with failure of the frontal nasal prominence to closeb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Mutant 2739-005-3 (E15.5) exhibits parallel outflow tracts and RAA which is diagnosed as DORV by EFIC imagingb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
EFIC Summaryb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Serial 2D EFIC image stack of 2739-005-3 (E15.5) in the coronal plane reveals Taussig Bing type DORV {A,D,D}, AVSD, common atrium, RAA, aberrant left subclavian artery forming vascular ring, ventricular non-compaction, left lung isomerism, left hepatic vein and right IVC connect to atria
Click thumbnail to play movie.
b2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Mutant 2739-005-3 (E15.5) is runted and pale. Mutant also exhibits hydrops, petechiae, and right micropthalmiab2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Mutant 2739-005-3 (E15.5) presents with micropthalmia of right eye, and cleft lipb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo
Mutant 2739-005-3 (E15.5) shows a cleft palateb2b2739Clo/b2b2739CloC57BL/6J-b2b2739Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory