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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2821Clo
Name: Mutant line 2821; Bench to Bassinet Program (B2B/CVDC), mutation 2821 Cecilia Lo
MGI ID: MGI:5570109
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2821-003-LA has heterotaxy with levocardia, TGA, right lung isomerism (4R/4L), and dextrogastriab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane of 2821-003-LA reveals TGA {A,D,D}, AVSD, RAA, bilateral PDAs forming vascular ring, left-sided IVC, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-LA has hypoplastic thymusb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-LA has malrotated and short gutb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-LA exhibits heterotaxy with dextroversion, TGA, left aortic arch, right lung isomerism (4R/4L), and polysplenia/hypoplastic spleenb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-LA exhibits heterotaxy with malrotated gut, left-sided stomach, hypoplastic spleen and right-sided pancreasb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane reveals of 2821-004-LA dextroversion, TGA {A,D,D}, AVSD, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-LA exhibits heterotaxy and has normal cilia motion
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-007-LA presents with heterotaxy with dextrocardia with TGA and dextrogastriab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-007-LA presents with dextrocardia and hypoplastic thymusb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-2 (E13.5) exhibits a cleft palateb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane of 2821-007-LA reveals dextrocardia {A,L,L}, TGA, AVSD, dual IVC, and right atrial isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D micro-MRI image stack of 2821-007-LA in the coronal plane reveals heterotaxy, dextrocardia, TGA, VSD, ASD, hemiazygous connection {A,L,L}, bilateral hapatic vein connected to both side atria, left lung isomerisim, and dextrogastria
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-007-LA exhibits heterotaxy with dextrocardia, TGA, and inverted liver lobation (2R/1L)b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-2 (E13.5) exhibits heterotaxy with dextrocardia and TGA, which is confirmed by EFIC imagingb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC stack of 2812-003-2 (E13.5) in the coronal plane reveals dextrocardia, TGA {A,L,L}, AVSD, common atrium, dual IVC, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-2 (E13.5) presents with hydrops and short snoutb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-2 (E13.5) exhibits heterotaxy with dextrocardia, TGA, and dextrogastriab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-2 (E13.5) exhibits a hypoplastic thymus and dextrocardiab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-2 (E13.5) presents with heterotaxy indicated by dextrocardia, TGA, and inverted liver lobationb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-3 (E13.5) exhibits heterotaxy with dextrocardia and anterior aorta which is diagnosed as TGA by EFIC imagingb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack of 2821-003-3 (E13.5) in the coronal plane reveals dextrocardia, TGA {I,L,L}, and AVSD
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-3 (E13.5) presents with heterotaxy with dextrocardia and levogastriab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-003-3 (E13.5) shows a hypoplastic thymusb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-007-4 (E15.5) presents with TGA, a right aortic arch (RAA), right lung isomerism (3R/3L), superior-inferior ventricles, and hypoplastic LV which is confirmed by EFIC imagingb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane of 2821-007-4 (E15.5) reveals superior-inferior ventricles {A,D,D}, TGA with intact ventricular septum, hypoplastic LV, mitral valve stenosis, intracardiac type TAPVR, ASD (type II), RAA, aberrant left subclavian artery from PA, dual IVC, right atrial isomerism, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-1 (E14.5) exhibits heterotaxy with dextrocardia, left aortic arch, left liver isomerism (2R/2L), hypoplastic lungs which were determined to be right isomerism by EFIC imaging and also an anterior aorta which is diagnosed as Taussig-Bing type DORVb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane of 2821-004-1 (E14.5) reveals dextrocardia {A(I),L,L}, Taussig-Bing type DORV, unbalanced AVSD with cushion, small RV, common atrium, intracardiac TAPVR, left-sided IVC, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Color flow spectral Doppler imaging of mutant 2821-004 (E14.5) in the sagittal view shows Ao originating from LV, and PA is overriding on interventricular septum, suggesting Tausig-Bing type DORV
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Color flow spectral Doppler imaging of mutant 2821-004 (E14.5) in the transverse view shows shunting between LV and RV, suggesting AVSD or VSD
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-1 (E14.5) shows petechiae and micrognathiab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-1 (E14.5) presents with a cleft palateb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-1 (E14.5) exhibits heterotaxy with dextrogastriab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-1 (E14.5) exhibits heterotaxy with dextrocardia, left aortic arch, left IVCand anterior aorta which is diagnosed as Taussig-Bing type DORV by EFIC imagingb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane of 2821-004-2 (E14.5) reveals dextrocardia, TGA, unbalanced AVSD, small RV, left PDA forming vascular ring, common atrium, intracardiac TAPVR, left IVC, right heptaic vein {A,L,L}, and right isomerism lung
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D micro-CT image stack of 2821-004-2 (E14.5) in the coronal plane reveals heterotaxy, mesocardia, TGA, unbalanced AVSD, small RV, common atrium, TAPVR (intra cardiac), right atrial isomerism, IVC connects middle to left side atrium, right aortic arch {A,L,L}, right lung isomerism, inverted liver, and dextrogastria
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-8 (E14.5) displays a right aortic arch (RAA) and TGA, which is confirmed by EFIC imagingb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
EFIC Summaryb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D EFIC image stack in the coronal plane of 2821-004-8 (E14.5) reveals TGA {A(S),D,D}, right aortic arch, unbalanced AVSD, intracardiac type TAPVR, small RV, trabeculated ventricular myocardium, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Serial 2D micro-CT image stack of 2821-004-8 (E14.5) reveals heterotaxy, levocardia, TGA, unbalanced AVSD, hypoplastic RV, right aortic arch {A,D,D}, and right lung isomerism
Click thumbnail to play movie.		b2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-8 (E14.5) displays levocardia and is diagnosed by EFIC as mesocardia to levocardiab2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Mutant 2821-004-8 (E14.5) exhibits right lung isomerism (3R/3L), which is confirmed by EFIC imagingb2b2821Clo/b2b2821CloC57BL/6J-b2b2821Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory