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Phenotype Images associated with this Allele
Nomenclature
Symbol: Amnb2b2259Clo
Name: amnionless; Bench to Bassinet Program (B2B/CVDC), mutation 2259 Cecilia Lo
MGI ID: MGI:5614775
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant (E14.5) shows malpositioned outflow tracts with possible right aortic arch.Amnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
EFIC SummaryAmnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
Serial 2D ECM image stack in the coronal plane of 2259-003-1 (E14.5) reveals double outlet right ventricle (DORV), subaortic VSD, right aortic arch, hypoplastic pulmonary artery, ventricular non-compaction, aberrant left subclavian artery forming incomplete vascular ring
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Amnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
Mutant (E14.5) presents with hydrops, left micropthalmia, and is runtedAmnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
EFIC SummaryAmnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
Serial 2D ECM image stack in the coronal plane of 2259-007-NA reveals double outlet right ventricle (DORV), subaortic ventricular septal defect (VSD), right aortic arch (RAA), hypoplastic pulmonary artery (PA), and biventricular hypertrophy.
Click thumbnail to play movie.
Amnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
Mutant exhibits malaligned sternal vertebrae.Amnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo
Mutant exhibits parallel outflow tracts with right aortic arch, which was diagnosed as double outlet right ventricle (DORV) with hypoplastic pulmonary artery (PA) by ECM histopathology.Amnb2b2259Clo/Amnb2b2259CloC57BL/6J-Amnb2b2259Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory