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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ephb4b2b2412Clo
Name: Eph receptor B4; Bench to Bassinet Program (B2B/CVDC), mutation 2412 Cecilia Lo
MGI ID: MGI:5614904
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2412-003-2 (E15.5) presents with parallel outflow tracts suggesting overriding aorta. Also observed is premature constriction of the patent ductus.Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
EFIC SummaryEphb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Serial 2D ECM image stack in the coronal plane of 2412-003-2 (E15.5) shows perimembranous VSD, overriding aorta, hypoplastic PA, aberrant right subclavian artery forming incomplete vascular ring
Click thumbnail to play movie.		Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Color flow spectral Doppler imaging of mutant 2412-003 (E15.5) in the transverse view shows shunting between LV and RV, suggesting VSD.
Click thumbnail to play movie.		Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Mutant 2412-003-2 (E15.5) exhibits cystic kidneys, and hydronephrosis confirmed by histology.Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Kidneys of mutant 2412-003-2 show severe cystic kidney disease.Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Mutant 2412-002-2 (E15.5) shows a pulmonary artery that is displaced suggesting overriding aorta, which is confirmed by ECM imaging.Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
EFIC SummaryEphb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Serial 2D ECM image stack in the coronal plane of 2412-002-2 (E15.5) reveals perimembranous VSD and overriding aorta.
Click thumbnail to play movie.		Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Mutant 2412-002-2 (E15.5) presents with hydronephrosis.Ephb4b2b2412Clo/Ephb4b2b2412CloC57BL/6J-Ephb4b2b2412Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory