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Phenotype Images associated with this Allele
Nomenclature
Symbol: Trappc10b2b2613Clo
Name: trafficking protein particle complex 10; Bench to Bassinet Program (B2B/CVDC), mutation 2613 Cecilia Lo
MGI ID: MGI:5615094
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant (E15.5) exhibits a hypoplastic thymus.Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Color flow spectral Doppler imaging of mutant in the transverse view shows a shunt at atrioventricular cushion indicating atrioventricular septal defect.
Click thumbnail to play movie.		Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
EFIC SummaryTrappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Serial 2D ECM image stack in the coronal plane of mutant (E15.5) reveals a muscular ventricular septal defect (mVSD) and ventricular non-compaction.
Click thumbnail to play movie.		Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Mutant (E15.5) has normal outflow by necropsy but is diagnosed with AVSD and muscular VSD (mVSD) by ECM imagingTrappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Mutant (E15.5) presents with a hypoplastic thymus.Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
EFIC SummaryTrappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Serial 2D ECM image stack in the coronal plane of mutant (E15.5) reveals atrioventricular septal defect (AVSD), muscular VSD (mVSD), ventricular non-compaction, and incomplete ventricular septum formation.
Click thumbnail to play movie.		Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Mutant (E15.5) is runted, and exhibits micrognathia, and microphthalmia of the left eye.Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Mutant (E15.5) presents with a cleft palate.Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
EFIC SummaryTrappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Serial 2D ECM image stack of mutant in the coronal plane reveals muscular VSD
Click thumbnail to play movie.		Trappc10b2b2613Clo/Trappc10b2b2613CloC57BL/6J-Trappc10b2b2613Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory