Phenotype Images associated with this Allele

Nomenclature

Symbol:	Foxh1^b2b2662Clo
Name:	forkhead box H1; Bench to Bassinet Program (B2B/CVDC), mutation 2662 Cecilia Lo
MGI ID:	MGI:5615244

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant exhibits displaced outflow tracts which is diagnosed as double outlet single ventricle, right aortic arch, and aberrant right subclavian artery forming incomplete vascular ring by ECM imaging	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	EFIC Summary	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial 2D ECM image stack of mutant in the coronal plane reveals double outlet single ventricle. {A,A(D),D} , right aortic arch, unbalanced atrioventricluar septal defect, common atrium, RAI, aberrant right subclavian artery forming incomplete vascular ring, and right lung isomerism Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant presents with severe craniofacial defects including cyclopia, agnathia with proboscis, and low-set ears.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant 2662-004-NA exhibits right lung isomerism (4 lobes on each side).	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant exhibits heterotaxy with levocardia, left aortic arch, right lung isomerism (3 lobes on each side), dextrogastria, and Taussig-Bing type double outlet right ventricle (DORV) that was diagnosed by ECM histopathology.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	EFIC Summary	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial 2D ECM image stack of mutant in the coronal plane reveals Taussig Bing type double outlet right ventricle {A,D,D}, atrioventricular septal defect (AVSD), common atrium, and right lung isomerism. Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant exhibits heterotaxy with mesocardia, right lung isomerism (3 lobes on each side), Taussig-Bing type double outlet right ventricle (DORV), hypoplastic left ventricle, right aortic arch, and dual inferior vena cava, which are all diagnosed by ECM imaging.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	EFIC Summary	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial 2D ECM image stack of mutant in the coronal plane reveals mesocardia {A,L,L}, Taussig Bing double outlet right ventricle, unbalanced atrioventricular septal defect, common atrium, hypoplastic LV, RAA, right inferior vena cava and left hepatic vein connecting to atrium, and right lung isomerism Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial 2D ECM image stack of mutant in the coronal plane of whole body reveals right diaphragmatic hernia. mesocardia, (A,L,L), Taussig Bing DORV, unbalanced AVSD, common atrium, hypoplatic LV, RAA, right IVC and left hepatic vein connect to atrium, right lung isomerism. Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant presents with malaligned sternum.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant shows severe craniofacial defects with anencephaly, acrania, agnathia, and anopthalmia.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant exhibits microstomia with skin tags that may be abnormally positioned pinnae.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant exhibits right diaphragmatic hernia with stomach in the thoracic cavity, and also seen is intestinal malrotation.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	EFIC Summary	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial 2D ECM image stack of mutant in the coronal plane reveals Taussig-Bing type DORV {A,D,D}, RAA, unbalanced AVSD, common atrium, hypoplastic LV, and right lung isomerism Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial micro-MRI image stack of mutant in the coronal plane reveals double outlet right ventricle (DORV), unbalanced atrioventricular septal defect (AVSD), hypoplastic LV. Bilateral anophthamial, craniofacial hypoplasia, microcephaly, micrognathia or agnathia. Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant (E14.5) exhibits heterotaxy with dextrocardia.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant (E14.5) shows heterotaxy with dextrocardia and anterior placement of the aorta, suggesting outflow tract malalignment defects.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Mutant (E14.5) presents with severe craniofacial defects including anencephaly, agnathia, anopthalmia, low-set ears, acrania, phenotypes consistent with otocephaly.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	EFIC Summary	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo
	Serial 2D ECM image stack of mutant (ED14.5) in the coronal plane reveals heterotaxy, dextrocardia, Taussig Bing type double outlet right ventricle (DORV), unbalanced atrioventricular septal defect, common atrium, IVC connected at the middle of the atrium {A,L,L}, TAPVR (to right SVC), aberrant right aortic arch and pulmonary arch anomalies forming incomplete vascular ring, aberrant semilunar valve formation (cushion like), and right lung isomerism. Click thumbnail to play movie.	Foxh1^b2b2662Clo/Foxh1^b2b2662Clo	C57BL/6J-Foxh1^b2b2662Clo

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