Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Bmp10^b2b2711Clo
Name:	bone morphogenetic protein 10; Bench to Bassinet Program (B2B/CVDC), mutation 2711 Cecilia Lo
MGI ID:	MGI:5616117

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant (E16.5) exhibits a hypoplastic thymus.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Mutant (E16.5) has parallel outflow tracts, indicating possible DORV which is confirmed by ECM. Mutant also shows hypoplastic PA and hypoplastic lungs.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	EFIC Summary	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Serial 2D ECM image stack of mutant (E16.5) shows DORV (TOF type), subaortic VSD, and hypoplastic PA. Click thumbnail to play movie.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Color flow spectral Doppler imaging of mutant in the saggital view shows hypoplastic PA with PA retrograde flow, overriding Ao and VSD suggesting Tetralogy of Fallot Click thumbnail to play movie.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Color flow spectral Doppler imaging of mutant in the saggital view shows hypoplastic pulmonary artery	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Color flow spectral Doppler imaging of mutant in the saggital view shows a shunt between left ventricle and right ventricle indicating VSD.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	2D imaging of mutant in the saggital view shows overriding aorta. Click thumbnail to play movie.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Mutant (E16.5) presents with hydrops, patechiae, and a curly tail.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo
	Mutant shows cystic kidneys with moderate tubule dilations.	Bmp10^b2b2711Clo/Bmp10^b2b2711Clo	C57BL/6J-Bmp10^b2b2711Clo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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