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Phenotype Images associated with this Allele
Nomenclature
Symbol: Bmp10b2b2711Clo
Name: bone morphogenetic protein 10; Bench to Bassinet Program (B2B/CVDC), mutation 2711 Cecilia Lo
MGI ID: MGI:5616117
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant (E16.5) exhibits a hypoplastic thymus.Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Mutant (E16.5) has parallel outflow tracts, indicating possible DORV which is confirmed by ECM. Mutant also shows hypoplastic PA and hypoplastic lungs.Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
EFIC SummaryBmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Serial 2D ECM image stack of mutant (E16.5) shows DORV (TOF type), subaortic VSD, and hypoplastic PA.
Click thumbnail to play movie.		Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Color flow spectral Doppler imaging of mutant in the saggital view shows hypoplastic PA with PA retrograde flow, overriding Ao and VSD suggesting Tetralogy of Fallot
Click thumbnail to play movie.		Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Color flow spectral Doppler imaging of mutant in the saggital view shows hypoplastic pulmonary arteryBmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Color flow spectral Doppler imaging of mutant in the saggital view shows a shunt between left ventricle and right ventricle indicating VSD.Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
2D imaging of mutant in the saggital view shows overriding aorta.
Click thumbnail to play movie.		Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Mutant (E16.5) presents with hydrops, patechiae, and a curly tail.Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Mutant shows cystic kidneys with moderate tubule dilations.Bmp10b2b2711Clo/Bmp10b2b2711CloC57BL/6J-Bmp10b2b2711Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory