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Phenotype Images associated with this Allele
Nomenclature
Symbol: Cplane2b2b2804Clo
Name: ciliogenesis and planar polarity effector 2; Bench to Bassinet Program (B2B/CVDC), mutation 2804 Cecilia Lo
MGI ID: MGI:5616147
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant (E14.5) shows persistent truncus arteriosus (PTA), and dual inferior vena cava (IVC), which was confirmed by ECM imaging.Cplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
EFIC SummaryCplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
Serial 2D EFIC image stack in the coronal plane of mutant (E14.5) reveals PTA {A,D,D(A)}, atrioventricular septa defects (AVSD), common atrium, dual inferior vena cava (IVC), absent pulmonary artery (PA) branch, and hypoplastic lungs with trachea and bronchi not identified.
Click thumbnail to play movie.		Cplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
Color flow spectral Doppler imaging of mutant (E14.5) in the sagittal view shows one great artery originating from heart with regurgitation, suggesting PTA.
Click thumbnail to play movie.		Cplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
Mutant (E14.5) exhibits preaxial digit duplication and central polydactyly, hydrops, micrognathia, and anophthalmia.Cplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
EFIC SummaryCplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
Serial 2D ECM image stack in the coronal plane of mutant (E14.5) reveals developmental arrest, persistent truncus arteriosus (PTA-Type 1), and cushion-like atrioventricular valve.
Click thumbnail to play movie.		Cplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
Mutant (E14.5) shows persistent truncus arteriosus (PTA), which was diagnosed by ECM imaging as PTA-type I.
Mutant (E14.5) shows polydactyly, micrognathia, short snout, and microphthalmiaCplane2b2b2804Clo/Cplane2b2b2804CloC57BL/6J-Cplane2b2b2804Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory