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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pdgfrbb2b2903Clo
Name: platelet derived growth factor receptor, beta polypeptide; Bench to Bassinet Program (B2B/CVDC), mutation 2903 Cecilia Lo
MGI ID: MGI:5618619
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
This image is from the Laboratory of Dr. Cecilia Lo, a member of the Cardiovascular Development Consortium (CvDC), Bench to Bassinet (B2B) program of the National Heart Lung and Blood Institute (NHLBI), and is displayed with the permission of the authors.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
EFIC SummaryPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Serial 2D ECM image stack in the coronal plane of mutant (E15.5) reveals overriding aorta, perimembranous VSD (pmVSD), and incomplete vascular ring.
Click thumbnail to play movie.		Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) exhibits hydrops and petechiae.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) displays hypoplastic thymus.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) presents abnormal placement of the great arteries, later diagnosed as double outlet right ventricle (DORV) by ECM histopathology.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
EFIC SummaryPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Serial 2D ECM image stack in the coronal plane of (E15.5) reveals double outlet right ventricle (DORV) and subaortic ventricular septal defect (VSD).
Click thumbnail to play movie.		Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Color flow spectral Doppler imaging of mutant (E15.5) in the sagittal view shows aorta overriding the ventricular septum, indicating double outlet right ventricle (DORV).Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) exhibits hydrops and petechiae.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) displays hypoplastic thymus.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) presents with abnormal arrangement of the outflow tract, later diagnosed as Tetralogy of Fallot (TOF) with overriding aorta, and hypoplastic pulmonary seen by ECM histopathology.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
EFIC SummaryPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Serial 2D ECM imaging in the coronal plane of mutant (E15.5) reveals Tetralogy of Fallot (TOF) with overriding aorta, atrioventricular septal defect (AVSD), and hypoplastic pulmonary artery (PA).
Click thumbnail to play movie.		Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) has petechiae, hydrops, and short forelimbs.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) presents with hypoplastic thymus.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
EFIC SummaryPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Serial 2D ECM image stack in the coronal plane of mutant (E15.5) reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), muscular ventricular septal defect (mVSD), and hypoplastic pulmonary artery (PA).
Click thumbnail to play movie.		Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) exhibits hydrops, petechiae, short snout, and mircrognathia.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) has clinodactyly on the left hindlimbPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) displays parallel outflow tracts which is diagnosed as double outlet right ventricle and hypoplastic pulmonary by ECM histopathology.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
EFIC SummaryPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Serial 2D ECM image stack in the coronal plane of mutant (E15.5) reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), and small pulmonary artery (PA).
Click thumbnail to play movie.		Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) is runted, has hydrops, petechiae, and micrognathia.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) presents with clinodactyly on hindlimb digits.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) has an abnormal arrangement of the outflow tracts which is diagnosd as overriding aorta, right aortic arch, and a hypoplastic transverse aorta forming vascular ring by ECM imaging.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
EFIC SummaryPdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Serial 2D ECM image stack in the coronal plane of mutant reveals overriding aorta, atrioventricular septal defect (AVSD), cushion-like AV valve, right aortic arch (RAA) with left patent ductus arteriosis (PDA), hypoplastic transverse aorta forming a vascular ring, aberrant left subclavian artery from left PDA-ascending aorta junction, ventricular non-compaction.
Click thumbnail to play movie.		Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Mutant (E15.5) exhibits micrognathia, hydrops, and petechiae.Pdgfrbb2b2903Clo/Pdgfrbb2b2903CloC57BL/6J-Pdgfrbb2b2903Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
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