Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Dock1^b2b3190Clo
Name:	dedicator of cytokinesis 1; Bench to Bassinet Program (B2B/CVDC), mutation 3190Cecilia Lo
MGI ID:	MGI:5618859
Synonyms:	DIctator

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant (E17.5) exhibits malaligned outflow tracts with hypoplastic pulmonary artery (PA) which was diagnosed by ECM histopathology as double outlet right ventricle (DORV) of Tetralogoy of Fallot subtype.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	EFIC Summary	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Serial 2D ECM image stack in the coronal plane of mutant (E17.5) reveals double outlet right ventricle (DORV) of the Tetralogy of Fallot subtype with pulmonary atresia and subaortic VSD. Click thumbnail to play movie.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (E17.5) has severe hydrops, short snout, and micrognathia.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (e17.5) has a hypoplastic thymus	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (E17.5) exhibits bilateral kidney hydronephrosis.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (E14.5) exhibits abnormal outflow tracts which is diagnosed as persistent truncus arterioles (PTA, Type 1) by ECM imaging.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	EFIC Summary	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Serial 2D ECM image stack in the coronal plane of mutant (E14.5) reveals persistent truncus arteriosus (PTA-type 1), atrioventricular septal defect (AVSD), and left patent ductus arteriosis (PDA). Click thumbnail to play movie.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (E14.5) exhibits hydrops, petechiae, and micrognathia.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (E14.5) has a hypoplastic thymus.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Mutant (E14.5) presents with malaligned outflow tracts, later diagnosed as double outlet right ventricle (DORV) by ECM histopathology.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	EFIC Summary	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo
	Serial 2D ECM image stack in the coronal plane of mutant (E14.5) reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), and cushion-like AV valves. Click thumbnail to play movie.	Dock1^b2b3190Clo/Dock1^b2b3190Clo	C57BL/6J-Dock1^b2b3190Clo

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