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Phenotype Images associated with this Allele
Nomenclature
Symbol: Pigvb2b2859Clo
Name: phosphatidylinositol glycan anchor biosynthesis, class V; Bench to Bassinet Program (B2B/CVDC), mutation 2859 Cecilia Lo
MGI ID: MGI:5645357
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2859-002-1 (E15.5) presents with outflow tract misalignment and a hypoplastic transverse aortic arch which is diagnosed as an overriding aorta by episcopic confocal histopathology.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
EFIC SummaryPigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Serial 2D episcopic confocal microscopy image stack of 2859-002-1 (E15.5) in the coronal plane reveals overriding aorta, pmVSD, and hypoplastic transverse aorta.
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Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Color flow spectral Doppler imaging of mutant 2859-002-1 (E15.5) in the sagittal view shows Ao riding over the interventricular septum, and blood flow in Ao is thin, suggesting overriding Ao with possible Ao stenosis
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-002-1 (E15.5) has microphthalmia and is runted.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) presents with abnormal arrangement of the outflow tracts which is diagnosed as DORV with a right aortic arch and a left patent ductus arteriosis by episcopic confocal histopathology.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-002-1 (E15.5) presents with hydronephrosis.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
EFIC SummaryPigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Play MovieSerial 2D episcopic confocal microscopy image stack of 2859-004-2 (E15.5) in the coronal plane reveals DORV, non-committed AVSD, RAA, and left PDA forming vascular ring.
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) presents with micrognathia, hydrops, and is runted.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) exhibits a cleft palate.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) shows a hypoplastic thymus.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) shows an abnormal arrangement of the outflow tracts, which is diagnosed as DORV by episcopic confocal histopathology.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) shows left duplex kidney with glomerular cysts.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
EFIC SummaryPigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Serial 2D episcopic confocal microscopy image stack of 2859-004-4 (E15.5) in the coronal plane reveals DORV and subaortic VSD.
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Color flow spectral Doppler imaging of mutant 2859-004-4 (E16.5) in the sagittal view shows two great arteries originating from RV predominantly, suggesting DORV
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) has microphthalmia.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) is runted, has hydrops, and has micrognathia.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) has a hypoplastic thymus.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory