About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Pigvb2b2859Clo
Name: phosphatidylinositol glycan anchor biosynthesis, class V; Bench to Bassinet Program (B2B/CVDC), mutation 2859 Cecilia Lo
MGI ID: MGI:5645357
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2859-002-1 (E15.5) presents with outflow tract misalignment and a hypoplastic transverse aortic arch which is diagnosed as an overriding aorta by episcopic confocal histopathology.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
EFIC SummaryPigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Serial 2D episcopic confocal microscopy image stack of 2859-002-1 (E15.5) in the coronal plane reveals overriding aorta, pmVSD, and hypoplastic transverse aorta.
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Color flow spectral Doppler imaging of mutant 2859-002-1 (E15.5) in the sagittal view shows Ao riding over the interventricular septum, and blood flow in Ao is thin, suggesting overriding Ao with possible Ao stenosis
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-002-1 (E15.5) has microphthalmia and is runted.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) presents with abnormal arrangement of the outflow tracts which is diagnosed as DORV with a right aortic arch and a left patent ductus arteriosis by episcopic confocal histopathology.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-002-1 (E15.5) presents with hydronephrosis.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
EFIC SummaryPigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Play MovieSerial 2D episcopic confocal microscopy image stack of 2859-004-2 (E15.5) in the coronal plane reveals DORV, non-committed AVSD, RAA, and left PDA forming vascular ring.
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) presents with micrognathia, hydrops, and is runted.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) exhibits a cleft palate.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-2 (E15.5) shows a hypoplastic thymus.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) shows an abnormal arrangement of the outflow tracts, which is diagnosed as DORV by episcopic confocal histopathology.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) shows left duplex kidney with glomerular cysts.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
EFIC SummaryPigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Serial 2D episcopic confocal microscopy image stack of 2859-004-4 (E15.5) in the coronal plane reveals DORV and subaortic VSD.
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Color flow spectral Doppler imaging of mutant 2859-004-4 (E16.5) in the sagittal view shows two great arteries originating from RV predominantly, suggesting DORV
Click thumbnail to play movie.
Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) has microphthalmia.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) is runted, has hydrops, and has micrognathia.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo
Mutant 2859-004-4 (E15.5) has a hypoplastic thymus.Pigvb2b2859Clo/Pigvb2b2859CloC57BL/6J-Pigvb2b2859Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory