Phenotype Images associated with this Allele

Nomenclature

Symbol:	Pigv^b2b2859Clo
Name:	phosphatidylinositol glycan anchor biosynthesis, class V; Bench to Bassinet Program (B2B/CVDC), mutation 2859 Cecilia Lo
MGI ID:	MGI:5645357

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 2859-002-1 (E15.5) presents with outflow tract misalignment and a hypoplastic transverse aortic arch which is diagnosed as an overriding aorta by episcopic confocal histopathology.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	EFIC Summary	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Serial 2D episcopic confocal microscopy image stack of 2859-002-1 (E15.5) in the coronal plane reveals overriding aorta, pmVSD, and hypoplastic transverse aorta. Click thumbnail to play movie.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Color flow spectral Doppler imaging of mutant 2859-002-1 (E15.5) in the sagittal view shows Ao riding over the interventricular septum, and blood flow in Ao is thin, suggesting overriding Ao with possible Ao stenosis Click thumbnail to play movie.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-002-1 (E15.5) has microphthalmia and is runted.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-2 (E15.5) presents with abnormal arrangement of the outflow tracts which is diagnosed as DORV with a right aortic arch and a left patent ductus arteriosis by episcopic confocal histopathology.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-002-1 (E15.5) presents with hydronephrosis.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	EFIC Summary	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Play MovieSerial 2D episcopic confocal microscopy image stack of 2859-004-2 (E15.5) in the coronal plane reveals DORV, non-committed AVSD, RAA, and left PDA forming vascular ring. Click thumbnail to play movie.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-2 (E15.5) presents with micrognathia, hydrops, and is runted.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-2 (E15.5) exhibits a cleft palate.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-2 (E15.5) shows a hypoplastic thymus.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-4 (E15.5) shows an abnormal arrangement of the outflow tracts, which is diagnosed as DORV by episcopic confocal histopathology.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-4 (E15.5) shows left duplex kidney with glomerular cysts.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	EFIC Summary	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Serial 2D episcopic confocal microscopy image stack of 2859-004-4 (E15.5) in the coronal plane reveals DORV and subaortic VSD. Click thumbnail to play movie.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Color flow spectral Doppler imaging of mutant 2859-004-4 (E16.5) in the sagittal view shows two great arteries originating from RV predominantly, suggesting DORV Click thumbnail to play movie.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-4 (E15.5) has microphthalmia.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-4 (E15.5) is runted, has hydrops, and has micrognathia.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo
	Mutant 2859-004-4 (E15.5) has a hypoplastic thymus.	Pigv^b2b2859Clo/Pigv^b2b2859Clo	C57BL/6J-Pigv^b2b2859Clo

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