| Mutant 2859-002-1 (E15.5) presents with outflow tract misalignment and a hypoplastic transverse aortic arch which is diagnosed as an overriding aorta by episcopic confocal histopathology. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| EFIC Summary | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Serial 2D episcopic confocal microscopy image stack of 2859-002-1 (E15.5) in the coronal plane reveals overriding aorta, pmVSD, and hypoplastic transverse aorta. Click thumbnail to play movie. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Color flow spectral Doppler imaging of mutant 2859-002-1 (E15.5) in the sagittal view shows Ao riding over the interventricular septum, and blood flow in Ao is thin, suggesting overriding Ao with possible Ao stenosis Click thumbnail to play movie. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-002-1 (E15.5) has microphthalmia and is runted. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-2 (E15.5) presents with abnormal arrangement of the outflow tracts which is diagnosed as DORV with a right aortic arch and a left patent ductus arteriosis by episcopic confocal histopathology. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-002-1 (E15.5) presents with hydronephrosis. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| EFIC Summary | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Play MovieSerial 2D episcopic confocal microscopy image stack of 2859-004-2 (E15.5) in the coronal plane reveals DORV, non-committed AVSD, RAA, and left PDA forming vascular ring. Click thumbnail to play movie. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-2 (E15.5) presents with micrognathia, hydrops, and is runted. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-2 (E15.5) exhibits a cleft palate. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-2 (E15.5) shows a hypoplastic thymus. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-4 (E15.5) shows an abnormal arrangement of the outflow tracts, which is diagnosed as DORV by episcopic confocal histopathology. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-4 (E15.5) shows left duplex kidney with glomerular cysts. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| EFIC Summary | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Serial 2D episcopic confocal microscopy image stack of 2859-004-4 (E15.5) in the coronal plane reveals DORV and subaortic VSD. Click thumbnail to play movie. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Color flow spectral Doppler imaging of mutant 2859-004-4 (E16.5) in the sagittal view shows two great arteries originating from RV predominantly, suggesting DORV Click thumbnail to play movie. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-4 (E15.5) has microphthalmia. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-4 (E15.5) is runted, has hydrops, and has micrognathia. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |
| Mutant 2859-004-4 (E15.5) has a hypoplastic thymus. | Pigvb2b2859Clo/Pigvb2b2859Clo | C57BL/6J-Pigvb2b2859Clo |