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Phenotype Images associated with this Allele
Nomenclature
Symbol: Lama5b2b2966.1Clo
Name: laminin, alpha 5; Bench to Bassinet Program (B2B/CVDC), mutation 2966, subline 1 Cecilia Lo
MGI ID: MGI:5646299
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2966-005-2 (E15.5) displays heterotaxy with mesocardia and left lung isomerism.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-2 (E15.5) exhibits abnormal liver lobation.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
2966-005-2 mutant exhibits mesocardia, hypoplastic right ventrical, perimembrnous and muscular VSDs, aberrant right subclavian artery forming incomplete vascular ring, left lung isomerism as seen by episcopic confocal microscopy.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Serial 2D episcopic confocal microscopy image stack in the coronal plane of 2966-005-2 (E15.5) reveals mesocardia, perimembranous ventricular septal defect (pmVSD), muscular ventricular septal defect (mVSD), aberrant right subclavian artery forming incomplete vascular ring, and left lung isomerism.
Click thumbnail to play movie.		b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-2 (E15.5) presents with exencephaly, anophthalmia, agnathia, low-set ears, and is runted.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-2 (E15.5) exhibits a curly tail and syndactyly/webbed feet.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-2 (E15.5) presents with only a left thymus gland which is hypoplastic.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-1 (E15.5) shows parallel outflow tracts which is diagnosed by episcopic confocal histopathology as overriding aorta.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
2966-005-1 mutant exhibits overriding aorta (Tetralogy of Fallot type), perimembranous ventricular septal disorder, small pulmonary artery, and aberrant right subclavian artery forming incomplete vascular ring as seen by episcopic confocal microscopy.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Serial 2D episcopic confocal microscopy image stack in the coronal plane of 2966-005-1 (E15.5) reveals overriding aorta (tetrology of fallot type), perimembranous ventricular septal defect (pmVSD), small pulmonary artery (PA) , and aberrant right subclavian artery forming an incomplete vascular ring.
Click thumbnail to play movie.		b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Color flow spectral Doppler imaging of mutant 2966-005-1 (E15.5) in the sagittal view shows only Ao riding over the interventricular septum with regurgitation, suggesting overriding Ao with possible PA stenosis
Click thumbnail to play movie.		b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-1 (E15.5) presents with exencephaly, low-set ears, and microphthalmia.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-1 (E15.5) shows exencephaly with narrow snout and microphthalmia.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-1 (E15.5) exhibits syndactyly and a curly tail.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-1 (E15.5) presents with absent right thymus gland and a hypoplastic left thymus gland.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-005-1 (E15.5) presents with abnormal possibly cystic right kidney and hypoplastic left kidneyb2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-004-NA shows a right aortic arch and fused outflow tracts which is diagnosed as persistent truncus arteriosis (PTA) (Type-I) with interrupted aortic arch (type B) by episcopic confocal microscopy histopathologyb2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
2966-004-NA mutant exhibits persistent truncus arteriosus (type 1), atrioventricular septal disorder, right aortic arch, interrupted aortic arch (type B), and abnormal 4th arch development as seen by episcopic confocal microscopy.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Serial 2D episcopic confocal microscopy image stack of 2966-004-NA in the coronal plane reveals persistent truncus arteriosis (PTA, Type-I), atrioventricular septal defect (AVSD), right aortic arch (RAA), interrupted aortic arch (IAA, type B) and abnormal 4th arch development.
Click thumbnail to play movie.		b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-004-NA exhibits a short snout, micrognathia, low set ears, microphthalmia of the right eye, microstomia, and syndactyly on all limbs.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-004-NA shows only one thymus gland.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-003-NA exhibits a hypoplastic thymus.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-003-NA shows a small RV and an abnormal arrangement of the outflow tracts, which is diagnosed as double outlet right ventricle by episcopic confocal histopathologyb2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
2966-003-NA mutant exhibits double outlet right ventricle, subaortic ventricular septal disorder, small right ventricle, aberrant right subclavian artery forming incomplete vascular ring as seen by episcopic confocal microscopy.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Serial 2D episcopic confocal microscopy image stack in the coronal plane of 2966-003-NA reveals double outlet right ventricle (DORV), sub aortic ventricular septal defect (VSD), small right ventricle (RV), and aberrant right subclavian artery forming incomplete vascular ring.
Click thumbnail to play movie.		b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Mutant 2966-003-NA exhibits right kidney agenesis.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
Left kidney from mutant 2966-003-NA has small cysts and tubular dilations.b2b2966Clo/b2b2966CloC57BL/6J-b2b2966Clo
Lama5b2b2966.1Clo/Lama5b2b2966.1CloC57BL/6J-Lama5b2b2966.1Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory