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Phenotype Images associated with this Allele
Nomenclature
Symbol: Wnt5ab2b3077.1Clo
Name: wingless-type MMTV integration site family, member 5A; Bench to Bassinet Program (B2B/CVDC), mutation 3077, subline 1 Cecilia Lo
MGI ID: MGI:5646613
Synonyms: Po
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 3077-006-2 (E15.5) exhibits parallel outflow tracts, pulmonary stenosis, and small left atrium later diagnosed as double outlet right ventricle (DORV), hypoplastic pulmonary artery, and hypoplastic left atrium by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-006-2 (E15.5) in the coronal plane reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), common atrium, hypoplastic pulmonary artery (PA), hypoplastic left atrium, and ventricular myocardial non-compaction.
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Color flow spectral Doppler imaging of mutant 3077-006-2 (E15.5) in the sagittal view shows only aorta overriding over septum, suggesting double outlet right ventricle (DORV) with pulmonary stenosis (PS) or pulmonary atresia.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) presents with hydrops, petechiae, short snout, micrognathia, short limbs, syndactyly, clubbed feet, and short tail.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) shows a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) presents with a cleft palate.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) exhibits a short gut.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) has an abnormal placement of the gonads and abnormal kidneys, later confirmed as duplex kidney with some glomerular cysts by histologyb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) exhibits duplex kidney with some glomerular cysts.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) exhibits a large, single outflow which was later diagnosed as persistent truncus arteriosis (PTA) by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D image stack of 3077-006-3 (E15.5) in the coronal plane reveals persistent truncus arteriosis (PTA) (Type 1).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Color flow spectral doppler imaging of 3077-006-3 (E15.5) in the sagittal view shows only one great artery originating from the heart indicating persistent truncus arteriosis (PTA).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) shows hydrops, petechiae, short snout, micrognathia, short limbs, clubbed feet, syndactuly, and short tail.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) exhibits a short gut.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) only has a right thymus gland which is extremely hypoplastic.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) shows a small left ventricle and a single outflow tract, later diagnosed as persistent truncus arteriosis (PTA) type 1 by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-006-1 (E15.5) in the coronal plane reveals persistent truncus arteriosis (PTA Type 1), atrioventricular septal defect (AVSD), and small left ventricle (LV).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) has syndactyly, short limbs, is runted, micrognathia, a short snout, a short tail, underdeveloped ear pinna, and low-set ears.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) presents with a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) shows a cleft palate.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) has hypoplastic thymusb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) exhibits hypoplastic lungs.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) presents with a short gutb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits only one outflow tract which is diagnosed by ECM imaging as persistent truncus arterioris (PTA) type II and small left ventricleb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-002-2 (ED14.5) in the coronal plane reveals persistent truncus arteriosis (Type II) with atrioventricular septal defect (AVSD), and small left ventricle (LV).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits abnormal thymuses.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits abnormally shaped kidneys which is diagnosed as bilateral duplex kidney with glomerular cysts by histopathologyb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) has bilateral duplex kidney with glomerular cysts.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits short snout, micrognathia, hydrops, low-set ears, and clubbed handsb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) displays only one outflow tract which is diagnosed as persistent truncus arteriosis (PTA) type 1 and small left ventricle by ECM imagingb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-002-1 (ED14.5) in the coronal plane reveals persistent truncus arteriosis (type I), atrioventricular septal defect (AVSD), and small left ventricular (LV).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) presents with micrognathia, short snout, hydrops, no tail, clubbed limbs, petechiae, and low-set earsb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) exhibits a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) shows a cleft palateb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
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11/12/2024
MGI 6.24 		The Jackson Laboratory