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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b3077.2Clo
Name: Mutant line 3077, subline 2 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 3077, subline 2 Cecilia Lo
MGI ID: MGI:5646614
Synonyms: Po
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 3077-006-4 (E15.5) exhibits aortic atresia with accessory anterior lung lobes, hypoplastic left atrium, and thickened left ventricle wall. This is diagnosed as aortic atresia, left venricle hypertrophy, and hypoplastic left heart syndrome (HLHS) spectrum heart by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Serial 2D ECM image stack of 3077-006-4 (E15.5) in the coronal plane reveals hypoplastic left heart syndrome with aortic atresia, mitral valve stenosis, and muscle bound hypoplastic left ventricle. Also noted was abnormal acccessory anterior lung lobes.
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
3D ECM reconstruction of 3077-006-4 shows accessory anterior lung lobes positioned above the atria.
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) presents with hydrops, short snout, micrognathia, short limbs, clubbed feet, syndactyly, and short tail.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) presents with a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) exhibits a cleft palate.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) shows a short gut.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) exhibits abnormally placed adrenal glands and cystic kidneys, later confirmed showing a few glomerular cysts by histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) shows some glomerular cysts.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory