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Phenotype Images associated with this Allele
Nomenclature
Symbol: Tbc1d32b2b3260.1Clo
Name: TBC1 domain family, member 32; Bench to Bassinet Program (B2B/CVDC), mutation 3260, subline 1 Cecilia Lo
MGI ID: MGI:5648205
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 3260-006-2 (E16.5) exhibited an abnormal arrangement of the outflow tracts which was diagnosed as DORV (TOF Type), hypoplastic pulmonary, long right PDA, right aortic arch, and aberrant left subclavian artery by episcopic confocal histopathologyb2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-006-2 (E16.5) presents with exencephaly, bilateral anopthalmia, low-set ears, micrognathia, and a short snout.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-1 (E17.5) presents with preaxial digit duplication of the forelimbs.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) shows abnormal outflow tracts which is diagnosed as pulmonary atresia, AVSD, right aortic arch, aberrant right subclavian artery forming an incomplete vascular ring, and a tracheoesophageal fistula by episcopic confocal histopathologyb2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) presents with hydrops, petechiae, bilateral anopthalmia, short snout, and micrognathia.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) exhibits preaxial digit duplication and syndactylyb2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) has bilateral duplex kidneyb2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-3 (E17.5) exhibits abnormal arrangement of the outflow tracts which is diagnosed as an overridng aorta, AVSD, hypoplastic pulmonary artery, an aberrant right subclavian artery forming an incomplete vascular ring, and a tracheoesophageal fistula by histopathology.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-1 (E17.5) shows displaced outflow tracts which is diagnosed as DORV, AVSD, and a hypoplastic pulmonary by episcopic confocal histopathologyb2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-1 (E17.5) presents with a small body trunk, bilateral anopthalmia, abnormal nose shape, short tail, short limbs, short snout, and micrognathiab2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) exhibits preaxial digit duplicationb2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
3260-003-2 mutant exhibits pulmonary atresia, atrioventricular septal defect, right aortic arch, aberrant right subclavian artery forming incomplete vascular ring, tracheosophageal fistula, and left lung isomerism as seen by episcopic confocal microscopy.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Serial 2D episcopic confocal microscopy image stack in the coronal plane of mutant 3260-003-2 reveals pulmonary atresia, atrioventricular septal defect, right aortic arch, aberrant right subclavian artery forming incomplete vascular ring, tracheosophageal fistula, and left lung isomerism.
Click thumbnail to play movie.		b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) exhibits a beak ilike snout.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) displays bilateral anopthalmia, short snout, and micrognathia.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Mutant 3260-003-2 (E17.5) presents with a beak ilike snout, bilateral anopthalmia, and preaxial digit duplication of the forelimbs and hindlimbs.b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
b2b3260Clo/b2b3260CloC57BL/6J-b2b3260Clo
Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1CloC57BL/6J-Tbc1d32b2b3260.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory