Phenotype Images associated with this Allele

Nomenclature

Symbol:	Ica1l^b2b3465Clo
Name:	islet cell autoantigen 1-like; Bench to Bassinet Program (B2B/CVDC), mutation 3465 Cecilia Lo
MGI ID:	MGI:5648234

Images for
Allele

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Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant 3465-007-1 (E17.5) exhibits abnormal arrangement of the great arteries which was diagnosed by episcopic confocal microscopy as ventricular non-compaction.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	3465-007-2 mutant exhibits ventricular non-compaction as seen by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-2 (E17.5) exhibits a cleft lip, dome shaped head, open eyes, and a protruding tongue.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-2 (E17.5) exhibits a dome shaped head, open eyes, short snout, micrognathia, kinky tail, and short limbs.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-2 (E17.5) exhibits abnormally attached limbs.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-1 (E17.5) exhibits abnormal arrangement of the great arteries which was diagnosed by episcopic confocal microscopy as double outlet right ventricle, atrioventricular septal defect, and ventricular non-compaction.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	3465-007-1 mutant exhibits double outlet right ventricle, atrioventricular septal defect, and ventricular non-compaction as seen by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-1 (E17.5) exhibits a dome shaped head, open eyes, short snout, micrognathia, kinky tail, and short limbs.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-1 (E17.5) exhibits a cleft lip, dome shaped head, open eyes, and a protruding tongue.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-1 (E17.5) exhibits abnormally attached limbs.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-3 (E17.5) presents with an abnormal arrangement of the outflow tracts which was diagnosed as double outlet right ventricle, subaortic ventricular septal defect, interrupted aortic arch, hypoplastic pulmonary, aberrant left subclavian artery formin incomplete vascular ring by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-3 (E17.5) exhibits hydronephrosis of the left kidney which was confirmed by histopathology.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	3465-007-3 mutant exhibits double outlet right ventricle, subaortic ventricular septal defect, interrupted aortic arch, hypoplastic pulmonary artery, aberrant subclavian artery forming incomplete vascular ring, and ventricular non-compaction as seen by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-3 (E17.5) exhibits micrognathia.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-4 (E17.5) exhibits abnormal arrangement of the outflow tracts which was diagnosed as perimembranous ventricular septal defect, overriding aorta (possible double outlet right ventricle) and a dilated right atrium by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	3465-007-4 mutant exhibits double outlet right ventricle, perimembranous ventricular septal disorder, and a dilated right atrium as seen by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Episcopic confocal microscopy serial image stack showed double outlet right ventricle, perimembranous ventricular septal disorder, and a dilated right atrium. Click thumbnail to play movie.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-4 (E17.5) exhibits hydronephrotic kidneys which was confirmed by histopathology.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Mutant 3465-007-5 (E17.5) displays abnormal arrangement of the great arteries which was diagnosed by episcopic confocal microscopy as double outlet right ventricle, subaortic ventricular septal defect, muscular ventricular septal defect, and right aortic arch.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	3465-007-5 mutant exhibits double outlet right ventricle, subaortic ventricular septal disorder, muscular ventricular septal disorder, and a right aortic arch as seen by episcopic confocal microscopy.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo
	Episcopic confocal microscopy serial image stack showed double outlet right ventricle, subaortic ventricular septal disorder, muscular ventricular septal disorder, and a right aortic arch. Click thumbnail to play movie.	Ica1l^b2b3465Clo/Ica1l^b2b3465Clo	C57BL/6J-Ica1l^b2b3465Clo

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