Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Snx10^{tm1a(EUCOMM)Raba}
Name:	sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino
MGI ID:	MGI:5690193
Synonyms:	Snx10^Neo-f

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice are growth retarded, have a tooth eruption defect and have bones that lack marrow cavities	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Deficiency of mineralized cortical bone in Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} bone shows endosteum filled with unresorbed cartilage, thin cortical bone, and non-mineralized osteoid covering the mineralized trabeculae	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Abnormal stomach in 3-week old Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Calcium supplementation can correct the rickets phenotype of Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Bone abnormalities in Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Ctsk^tm1(cre)Ska/Ctsk^tm1(cre)Ska and Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice	Ctsk^tm1(cre)Ska/Ctsk⁺ Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} oseoclasts are unable to acidify, have impaired endosomal pathways, and have defective ruffled borders	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} and Tcirg1^tm1Ypl/Tcirg1^tm1Ypl mice show osteopetrorickets	Tcirg1^tm1Ypl/Tcirg1^tm1Ypl	involves: 129S4/SvJae * C57BL/6J
		Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J
	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice display reduced zymogenic cell granular size and abundance	Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J

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