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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b811Clo
Name: Mutant line 811 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 811 Cecilia Lo
MGI ID: MGI:5696169
Synonyms: Shar-pei
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 811-058-LB exhibits inverted outflow that is diagnosed with overriding aorta by EFIC imagingDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-058-LB presents with situs inversus totalis with dextrocardia, dextrogastria, and inverted lung and liver lobationDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
EFIC SummaryDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Serial 2D EFIC image stack in the coronal plane of 811-058-LB reveals dextrocardia, overriding aorta, and pmVSD
Click thumbnail to play movie.		Dnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-018-LA exhibits situs inversus totalis with dextrocardia and inverted lung lobationDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-018-LA presents with situs inversus totalis including dextrocardia and dextrogastriaDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
EFIC SummaryDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Serial 2D EFIC image stack in the coronal plane of 811-018-LA reveals mirror image dextrocardia {I,L,I}
Click thumbnail to play movie.		Dnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-058-LE exhibits heterotaxy with dextrocardia, inverted lung and liver lobation, dextrogastriaDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-058-LE has dextrocardia with an anterior aorta, which is diagnosed as TGA by EFIC imagingDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
EFIC SummaryDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Serial 2D EFIC image stack in the coronal plane of 811-058-LE reveals dextrocardia, TGA {I,L,L}, coronary fistula, and pmVSD
Click thumbnail to play movie.		Dnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-020-LB exhibits situs inversus totalis with dextrocardia, dextrogastria, and inverted lung and liver lobationDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
EFIC SummaryDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Serial 2D EFIC image stack in the coronal plane of 811-020-LB shows dextrocardia {A,L,L}, AVSD, mVSD, ventricular noncompaction, inverted hemiazygous continuation, and right atrial isomerism
Click thumbnail to play movie.		Dnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Mutant 811-020-LB has malaligned sternal vertebraDnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
Videomicroscopy of tracheal airway reveals immotile cilia
Click thumbnail to play movie.		Dnaaf4b2b811.1Clo/Dnaaf4b2b811.1CloC57BL/6J-Dnaaf4b2b811.1Clo
b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
EFIC Summaryb2b811Clo/b2b811CloC57BL/6J-b2b811Clo
b2b811.2Clo/b2b811.2CloC57BL/6J-b2b811.2Clo
2D serial EFIC image stack in the coronal plane of 811-006-NB reveals pmVSD and biventricular hypertrophy
Click thumbnail to play movie.		b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
b2b811.2Clo/b2b811.2CloC57BL/6J-b2b811.2Clo
Coronal movie obtained by micro-CT scan reveals perimembranous VSD
Click thumbnail to play movie.		b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
b2b811.2Clo/b2b811.2CloC57BL/6J-b2b811.2Clo
Transverse movie obtained by micro-CT scan reveals perimembarnous VSD
Click thumbnail to play movie.		b2b811Clo/b2b811CloC57BL/6J-b2b811Clo
b2b811.2Clo/b2b811.2CloC57BL/6J-b2b811.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory